IN VITRO EFFECT OF α-TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION

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GHAFARI M.A.; MOJAB S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Pharmaceutical Research Year:2007 | Volume:6 | Issue:4 Page(s): 265-271

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Title

IN VITRO EFFECT OF α-TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION

Author(s)

GHAFARI M.A. | MOJAB S. | Issue Writer Certificate

Keywords

LOW DENSITY LIPOPROTEIN (LDL)

GLYCATION

α-TOCOPHEROL

ASCORBIC ACID

LYCOPENE

Abstract

Nonenzymatic GLYCATION of low density lipoprotein (LDL) is a reaction of glucose and other reducing sugars with apolipoprotein B100 (apo-B100) lysine residues. In diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. The objective of this study was to investigate in vitro effects of a-tocopherol, ASCORBIC ACID and LYCOPENE on LDL GLYCATION.LDL was isolated from EDTA-plasma by ultracentrifugation using a single step discontinuous gradient. LDL and glucose were incubated without and with different concentrations of LYCOPENE, ASCORBIC ACID and a-tocopherol. LDL GLYCATION were estimated by sodium periodate assay.Based on this study results, a-tocopherol, ASCORBIC ACID and LYCOPENE decrease LDL GLYCATION in a dose dependent manner. The electrophoretic mobility of glycated LDL decreased in presence these nutrients. These effects may be due to antioxidant properties of these nutrients and may have a role in ameliorating atherosclerotic risk of patients with diabetes mellitus.

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APA: Copy

GHAFARI, M.A., & MOJAB, S.. (2007). IN VITRO EFFECT OF α-TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 6(4), 265-271. SID. https://sid.ir/paper/287656/en

Vancouver: Copy

GHAFARI M.A., MOJAB S.. IN VITRO EFFECT OF α-TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2007;6(4):265-271. Available from: https://sid.ir/paper/287656/en

IEEE: Copy

M.A. GHAFARI, and S. MOJAB, “IN VITRO EFFECT OF α-TOCOPHEROL, ASCORBIC ACID AND LYCOPENE ON LOW DENSITY LIPOPROTEIN GLYCATION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 6, no. 4, pp. 265–271, 2007, [Online]. Available: https://sid.ir/paper/287656/en

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