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Paper Information

Journal:   JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)   SPRING 2007 , Volume 7 , Number 1 (23); Page(s) 57 To 61.
 
Paper: 

THE COMPARISON OF VAGINAL AND ORAL FORM OF BROMOCRIPTIN IN TERMS OF SIDE EFFECTS RATE AND ITS CONTINUOUS CONSUMPTION IN PATIENTS REFERRING GYNECOLOGIC CLINIC

 
 
Author(s):  KAHNAMOUEI AGHDAM F.*, ASAD ZADEH MONIR F., AMANI F.
 
* OBSTETRICS AND GYNECOLOGY DEPT., FACULTY OF MEDICINE, ARDABIL UNIVERSITY OF MEDICAL SCIENCES, ARDABIL, IRAN
 
Abstract: 
Background and Objectives: Hyper prolactinemia is a disorder which is presented in clinical forms of galatrrhea infertility, menstural disorder, hirsotism and PMS.
Bromocriptin is agonist of dopamine and a drug for treatment of this disorder. Because of the necessity in continuous consumption of this drug (even for many years), the acceptance of the patients to the drug is important. In the present study the side-effects and acceptance level of patients to bromocriptin for the two forms of oral and vaginal use were studied.
Methods: This study is a single-blinded clinical trial. Cases of study were patients referring Gynecology clinic with complaints of "Galactoria, Hirsotism, Menstural disorders and infertility." The samples were 180 (two groups of 90 members each) and the length of study was two years. The samples were divided into two groups, (oral & vaginal). Before the start of the study, cases underwent, in terms of systemic and local complication, systemic and gynceologic examination to control systemic and local side effects. After health assurance of other systems, drugs were administered in two forms one group oral and the other group vaginal. The data was collected on the basis of questimnaire and analyzed by SPSS.
Results: This study showed the side effects of Bromcriptin in oral-forms they were 100% and for vaginal-from they were 43.2%. Most of the side effects in oral from were nausea 38.9% and in vaginal from was vaginal itching (22.3%). Vertigo in oral forms was more than vaginal form (27.8% to 2.3%). Hypotension was seen in 11.2% of oral forms but not in vaginal al form. About 51.2% of oral form group had more than two complications. In both groups the most complications were seem within the first ten days, 37.8% and 66.7%). Severity of side effects in 31.2% of oral forms and 11% of vaginal forms were so tense that resulted to patients discontinuation of the drug.
Conclusion: There is a significant difference between severity, intensity and kind of complications in the forms of oral and vaginal use of Branocriptin and acceptance and duration of drug intake in vaginal forms is more than oral forms.
 
Keyword(s): ORAL BROMOCRIPTIN, BROMOCRIPTION, VAGINAL, SIDE EFFECTS, DRUG ACCEPTANCE
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

KAHNAMOUEI AGHDAM, F., & ASAD ZADEH MONIR, F., & AMANI, F. (2007). THE COMPARISON OF VAGINAL AND ORAL FORM OF BROMOCRIPTIN IN TERMS OF SIDE EFFECTS RATE AND ITS CONTINUOUS CONSUMPTION IN PATIENTS REFERRING GYNECOLOGIC CLINIC. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 7(1 (23)), 57-61. https://www.sid.ir/en/journal/ViewPaper.aspx?id=101002



Vancouver: Copy

KAHNAMOUEI AGHDAM F., ASAD ZADEH MONIR F., AMANI F.. THE COMPARISON OF VAGINAL AND ORAL FORM OF BROMOCRIPTIN IN TERMS OF SIDE EFFECTS RATE AND ITS CONTINUOUS CONSUMPTION IN PATIENTS REFERRING GYNECOLOGIC CLINIC. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS). 2007 [cited 2021October27];7(1 (23)):57-61. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101002



IEEE: Copy

KAHNAMOUEI AGHDAM, F., ASAD ZADEH MONIR, F., AMANI, F., 2007. THE COMPARISON OF VAGINAL AND ORAL FORM OF BROMOCRIPTIN IN TERMS OF SIDE EFFECTS RATE AND ITS CONTINUOUS CONSUMPTION IN PATIENTS REFERRING GYNECOLOGIC CLINIC. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), [online] 7(1 (23)), pp.57-61. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101002.



 
 
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