CHRONIC STRESS INHIBITION OF ULTRA LOW DOSE MORPHINE-INDUCED HYPERALGESIA AND HPA AXIS ROLE

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FEREYDOUNI M.; SEMNANIAN S.; JAVAN M.; AHMADIAN A.A.H.

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

CHRONIC STRESS INHIBITION OF ULTRA LOW DOSE MORPHINE-INDUCED HYPERALGESIA AND HPA AXIS ROLE

Author(s)

FEREYDOUNI M. | SEMNANIAN S. | JAVAN M. | AHMADIAN A.A.H.

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Abstract

Gs signaling pathway seems to be important in hyperalgesic effect of morphine at ultra low dose (ULD), prevention of this pathway can inhibit development of tolerance to analgesic effect of morphine; chronic stress can also inhibit this tolerance formation. So can chronic stress affect morphine-induced hyperalgesia (Gs signaling)? Male Wistar (180-230gr) rats were under Tail Flick test to evaluate nociception. Forced swim stress, (5min/day) in water (20±1oC) is performed individually and nociceptive threshold was assessed 24 h after 5th stress session and 30 min after ULD morphine (1μg/kg i.p.) at the same time. Tests repeated for adrenalectomized (ADX) and sham-operated rats. Dexamethasone (2mg/kg i.p.) was used instead of stress. Data shows a hyperalgesia 24 h after 5th stress session in stressed and sham-operated stressed animals (p<0.01). At the same time chronic stress inhibited ULD morphine hyperalgesia and an analgesic effect is procuced (p<0.01). Chronic dexamethasone same as chronic stress was able to produce hyperalgesia (p<0.001) but could not change the hyperalgesic effect of ULD morphine. In ADX animal’s chronic stress produced neither hyperalgesia nor a change in morphine-induced hyperalgesia. Oseltamivir can inhibit morphine induced hyperalgesia but it couldn't able to inhibit stress hyperalgesia. Therefore it seems that the hyperalgesic effect of chronic stress is related to adrenal activity but not trough Gs signaling activation. The effect of chronic stress Inhibition of ULD morphine-hyperalgesia shows a negative influence on Gs signaling. Normal function of HPA axis is needed for the later effect of chronic stress and this effect is a probable mechanism by which chronic stress can inhibit morphine analgesic tolerance at least in part.

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APA: Copy

FEREYDOUNI, M., SEMNANIAN, S., JAVAN, M., & AHMADIAN, A.A.H.. (2007). CHRONIC STRESS INHIBITION OF ULTRA LOW DOSE MORPHINE-INDUCED HYPERALGESIA AND HPA AXIS ROLE. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904980/en

Vancouver: Copy

FEREYDOUNI M., SEMNANIAN S., JAVAN M., AHMADIAN A.A.H.. CHRONIC STRESS INHIBITION OF ULTRA LOW DOSE MORPHINE-INDUCED HYPERALGESIA AND HPA AXIS ROLE. 2007. Available from: https://sid.ir/paper/904980/en

IEEE: Copy

M. FEREYDOUNI, S. SEMNANIAN, M. JAVAN, and A.A.H. AHMADIAN, “CHRONIC STRESS INHIBITION OF ULTRA LOW DOSE MORPHINE-INDUCED HYPERALGESIA AND HPA AXIS ROLE,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904980/en

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