THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS

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AZIZI P.; MOUADAB M.; HASANPOUR EZATI M.; HAGHPARAST ABAS

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS

Author(s)

AZIZI P. | MOUADAB M. | HASANPOUR EZATI M. | HAGHPARAST ABAS

Keywords

REWARD

CB1 RECEPTOR

SENSITIZATION

NUCLEUS ACCUMBENS

ACQUISITION

RAT

Abstract

It has been shown that cannabinoids interact with the opiate system in REWARDrelated behaviors and in animal models of addiction. In the present study, the effects of bilateral intra-accumbal administration of AM251, a CB1 RECEPTOR antagonist, on the ACQUISITION of ineffective dose of morphine-induced conditioned place preference (CPP) in morphine-sensitized RATs was studied. The results showed that subcutaneous (s.c.) administration of morphine (0.25, 0.5, 0.75, 1, 2.5 and 5 mg/kg) induced CPP only at the dose of 5 mg/kg. In addition, repeated administration of morphine (5 mg/kg; s.c.), once daily for three days that followed by 5 days without any treatment (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 μl per side) reduced the ACQUISITION of morphine-induced CPP in morphine-sensitized RATs in a dose dependent manner. Bilateral intraaccumbal administration of neither saline nor DMSO (0.5 μl/side) had effects on the ACQUISITION of morphine-induced CPP in sensitized RATs. The results indicated that CB1 RECEPTOR within the NUCLEUS ACCUMBENS is involved in the SENSITIZATION to opiates.

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APA: Copy

AZIZI, P., MOUADAB, M., HASANPOUR EZATI, M., & HAGHPARAST, ABAS. (2009). THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903541/en

Vancouver: Copy

AZIZI P., MOUADAB M., HASANPOUR EZATI M., HAGHPARAST ABAS. THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS. 2009. Available from: https://sid.ir/paper/903541/en

IEEE: Copy

P. AZIZI, M. MOUADAB, M. HASANPOUR EZATI, and ABAS HAGHPARAST, “THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903541/en

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