The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats

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Fallahpour Nooshabadi Seyed Ali Akbar; KAZEMZADEH YASER; GORZI ALI

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Journal Paper

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Journal: Ebnesina Year:2021 | Volume:22 | Issue:4 (73) Page(s): 89-94

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Title

The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats

Author(s)

Fallahpour Nooshabadi Seyed Ali Akbar | KAZEMZADEH YASER | GORZI ALI | Issue Writer Certificate

Keywords

Type 2 DiabetesQ1

Blood GlucoseQ1

Insulin ResistanceQ1

HypoxiaQ2

PGC-1-alpha ProteinQ1

Abstract

Background: It has been observed that PGC-1α content decreases in Type 2 Diabetes. In addition, Hypoxia has been introduced as a new therapeutic intervention in Type 2 Diabetes. Therefore, the aim of this study was to evaluate the effect of eight weeks of daily normobaric Hypoxia (60 minutes) on PGC-1α content of soleus muscle, Insulin Resistance, and fasting glucose in type 2 diabetic rats. Materials and methods: In this study, 24 male Wistar rats were divided into three groups: control, diabetic, and diabetic Hypoxia. In diabetic groups, induction of diabetes was performed by HFD-STZ method. The plan consisted of eight weeks, five sessions per week and 60 minutes of exposure to normobaric Hypoxia with 14. 4% oxygen in the diabetic Hypoxia group in each session. At the end, tissue and blood samples were extracted for analysis. Statistical analysis was performed by one-way analysis of variance. Results: The results of analysis of variance showed a significant difference in all three variables (p=0. 0001). The results of post hoc test indicated a significant difference in PGC-1α between control and diabetic groups (p=0. 0001), between control and diabetic Hypoxia (p=0. 0001), and between diabetic and diabetic Hypoxia (p=0. 009). Also, the post hoc test among three groups showed a significant difference (p=0. 0001) in variables of fasting glucose and resistance to insulin. Conclusion: Due to the effect of normobaric Hypoxia on the increase of PGC-1α , the decrease of fasting glucose, and resistance to insulin, normobaric Hypoxia can be used as a new treatment strategy in Type 2 Diabetes.

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Cites

The Effect of Eight Weeks of Resistance Training Under Hypoxia on Metabolic Parameters and Muscle Tissue Regeneration in Male Wistar Rats with Type 2 Diabetes

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APA: Copy

Fallahpour Nooshabadi, Seyed Ali Akbar, KAZEMZADEH, YASER, & GORZI, ALI. (2021). The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats. EBNESINA, 22(4 (73) ), 89-94. SID. https://sid.ir/paper/416211/en

Vancouver: Copy

Fallahpour Nooshabadi Seyed Ali Akbar, KAZEMZADEH YASER, GORZI ALI. The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats. EBNESINA[Internet]. 2021;22(4 (73) ):89-94. Available from: https://sid.ir/paper/416211/en

IEEE: Copy

Seyed Ali Akbar Fallahpour Nooshabadi, YASER KAZEMZADEH, and ALI GORZI, “The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats,” EBNESINA, vol. 22, no. 4 (73) , pp. 89–94, 2021, [Online]. Available: https://sid.ir/paper/416211/en

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