EFFECTS OF CEREBROLYSIN ON FUNCTIONAL RECOVERY IN PATIENTS WITH SEVERE DISABILITY AFTER TRAUMATIC BRAIN INJURY; A PROSPECTIVE COHORT STUDY

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KHALILI HOSSEINALI; NIAKAN AMIN; GHAFFARPASAND FARIBORZ

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Journal: Iranian Journal of Neurosurgery Year:2016 | Volume:2 | Issue:SUP3 Page(s): 0-0

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Title

EFFECTS OF CEREBROLYSIN ON FUNCTIONAL RECOVERY IN PATIENTS WITH SEVERE DISABILITY AFTER TRAUMATIC BRAIN INJURY; A PROSPECTIVE COHORT STUDY

Author(s)

KHALILI HOSSEINALI | NIAKAN AMIN | GHAFFARPASAND FARIBORZ

Keywords

TRAUMATIC BRAIN INJURY (TBI)

CEREBROLYSIN

FUNCTIONAL RECOVERY

PROGNOSIS

SEVERE DISABILITY

Abstract

Background & Aim: An attempt was made To determine the effects of CEREBROLYSIN on FUNCTIONAL RECOVERY in patients with SEVERE DISABILITY after traumatic brain injury (T BI).Methods & Materials/Patients: This was a prospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16 years) with SEVERE DISABILITY (GOS of 2 and 3) 1-month after trauma. Patients received CEREBROLYSIN (n=65) or nothing (n=64) based on their preference. They were matched regarding the baseline characteristics including age, gender, GCS on admission, pupil reactivity and Rotterdam score. CEREBROLYSIN was administered intravenously in 10 mL dosage daily for 30 days. Patients were followed for 3 and 6 months and Glasgow Outcome Scale Extension (GOSE) was recorded. The outcome scales were compared between the two studied groups.Results: Overall, we included 129 patients with SEVERE DISABILITY 1-month after TBI. The baseline characteristics were comparable between groups. We found out that GOSE in 3-months (p=0.017) and 6-month (p=0.009) was significantly higher in those receiving CEREBROLYSIN. CEREBROLYSIN administration was associated with lower mortality rate, and higher good recovery after 6 months of therapy (p=0.024). CEREBROLYSIN administration was also associated with more favorable outcome (p=0.043). CEREBROLYSIN was associated with higher seizure rate (p=0.042).Conclusion: CEREBROLYSIN administration in patients with SEVERE DISABILITY after TBI is associated with improved FUNCTIONAL RECOVERY; It decreases mortality rate and increases favorable outcome. Seizure is important side effect of CEREBROLYSIN administration in TBI patients.

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APA: Copy

KHALILI, HOSSEINALI, NIAKAN, AMIN, & GHAFFARPASAND, FARIBORZ. (2016). EFFECTS OF CEREBROLYSIN ON FUNCTIONAL RECOVERY IN PATIENTS WITH SEVERE DISABILITY AFTER TRAUMATIC BRAIN INJURY; A PROSPECTIVE COHORT STUDY. IRANIAN JOURNAL OF NEUROSURGERY, 2(SUP3), 0-0. SID. https://sid.ir/paper/351578/en

Vancouver: Copy

KHALILI HOSSEINALI, NIAKAN AMIN, GHAFFARPASAND FARIBORZ. EFFECTS OF CEREBROLYSIN ON FUNCTIONAL RECOVERY IN PATIENTS WITH SEVERE DISABILITY AFTER TRAUMATIC BRAIN INJURY; A PROSPECTIVE COHORT STUDY. IRANIAN JOURNAL OF NEUROSURGERY[Internet]. 2016;2(SUP3):0-0. Available from: https://sid.ir/paper/351578/en

IEEE: Copy

HOSSEINALI KHALILI, AMIN NIAKAN, and FARIBORZ GHAFFARPASAND, “EFFECTS OF CEREBROLYSIN ON FUNCTIONAL RECOVERY IN PATIENTS WITH SEVERE DISABILITY AFTER TRAUMATIC BRAIN INJURY; A PROSPECTIVE COHORT STUDY,” IRANIAN JOURNAL OF NEUROSURGERY, vol. 2, no. SUP3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/351578/en

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