COMPARISON OF THE ANXIOLYTIC EFFECTS OF SAFFRON (CROCUS SATIVUS. L) AND DIAZEPAM BEFORE HERNIORRHAPHY SURGERY: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL

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BASIRI MOGHADAM MAHDI; HAMZEI ARASH; MOSLEM ALIREZA; PASBAN NOGHABI SAEID; GHORBANI NEMATOLLAH; GHENAATI JAFAR

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Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:3 Page(s): 0-0

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Title

COMPARISON OF THE ANXIOLYTIC EFFECTS OF SAFFRON (CROCUS SATIVUS. L) AND DIAZEPAM BEFORE HERNIORRHAPHY SURGERY: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL

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Keywords

PRESURGERY ANXIETY

DIAZEPAM

SAFFRON (CROCUS SATIVUS L.)

Abstract

Background: Anxiety is an unpleasant state of feeling agitation and pressure induced by the patient’s fear of hospitalization, anesthesia or surgery.Objectives: The present study is aimed to compare the effects of dried extract of saffron and DIAZEPAM on soothing the preherniorrhaphy surgery anxiety.Patients and Methods: In this double blind clinical study, during 8 months, 102 patients were studied in 2012. all the patients in intervention group (n = 50) received 25 mg dried extract of saffron and participants in control group (n = 52) received 5 mg oral DIAZEPAM. Level of anxiety of the patients was measured using speillberger state-trait anxiety inventory (STAI) before intervention and 3 hours after administration (immediately after entering the surgery room) filled out by the patients. The patients in the two groups were compared concerning level of anxiety before/after intervention. The two groups of participants had almost equal demographic features.Results: According to the results, level of trait anxiety in the intervention groups decreased from 37.24±7.4 to 34.72±7.45 and the trend among the control group was vice versa and increased from 34.51±10.74 to 38.8±9.97. The data showed significant relation between level of trait anxiety before and after intervention in control and experiment groups (P = 0.019).Conclusions: Considering the findings, in comparison to DIAZEPAM, dried extract of saffron at 25 mg dose is more effective on soothing anxiety.

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APA: Copy

BASIRI MOGHADAM, MAHDI, HAMZEI, ARASH, MOSLEM, ALIREZA, PASBAN NOGHABI, SAEID, GHORBANI, NEMATOLLAH, & GHENAATI, JAFAR. (2016). COMPARISON OF THE ANXIOLYTIC EFFECTS OF SAFFRON (CROCUS SATIVUS. L) AND DIAZEPAM BEFORE HERNIORRHAPHY SURGERY: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(3), 0-0. SID. https://sid.ir/paper/683561/en

Vancouver: Copy

BASIRI MOGHADAM MAHDI, HAMZEI ARASH, MOSLEM ALIREZA, PASBAN NOGHABI SAEID, GHORBANI NEMATOLLAH, GHENAATI JAFAR. COMPARISON OF THE ANXIOLYTIC EFFECTS OF SAFFRON (CROCUS SATIVUS. L) AND DIAZEPAM BEFORE HERNIORRHAPHY SURGERY: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(3):0-0. Available from: https://sid.ir/paper/683561/en

IEEE: Copy

MAHDI BASIRI MOGHADAM, ARASH HAMZEI, ALIREZA MOSLEM, SAEID PASBAN NOGHABI, NEMATOLLAH GHORBANI, and JAFAR GHENAATI, “COMPARISON OF THE ANXIOLYTIC EFFECTS OF SAFFRON (CROCUS SATIVUS. L) AND DIAZEPAM BEFORE HERNIORRHAPHY SURGERY: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/683561/en

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