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Paper Information

Journal:   IRANIAN JOURNAL OF DERMATOLOGY   Summer 2004 , Volume 7 , Number 4; Page(s) 209 To 218.
 
Paper: 

A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL

 
 
Author(s):  FIROUZ A.R.*, KHATAMI A.R., KHAMESIPOUR A., NASIRI KASHANI M., NILFOROUSHZADEH MOHAMMAD ALI, BEHNIA F., PAZOUKI TOROUDI H.R., DOULATI Y.
 
* Center for Research and Training in Skin Diseases and Leprosy,79th Taleghani Avenue, Tehran 14166, Iran
 
Abstract: 

Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnS04) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnS04 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL.

Patients & Methods: Seventy-two patients with CL with a duration of less than 8 weeks were recruited in a randomized, double-blind, clinical trial in Isfahan province-an area endemic for Leishmania major-after giving written informed consent. They were treated with 6 weekly intralesional injections of either 2% sterile ZnSO4 solutions or Glucantime prepared in identical vials. The primary outcome measure was complete re-epithelialization of CL lesions.
Results: Among 36 patients with 53 lesions treated with ZnS04 and 36 patients with 53 lesions treated with Glucantime, 13patients with 19 lesions and 22 patients with 31 lesions completed the trial, respectively. Inadequacy of treatment was the main reason for drop-out in 12 (33.3%) and 2 (5.5%) patients in ZnS04 and Glucantime groups, respectively (P<0.05). Complete re-epithelialization was observed in 2 (10.5%) and 19(61.3%) lesions 1 week after the end of
treatment in the ZnS04 and Glucantime groups, respectively (P<0.05).

Conclusion: A six-week course of weekly intralesional injections of 2% ZnSO4 solution was less effective than Glucantime in the treatment of acute Old World CL.

 

 

 

 
Keyword(s): CLINICAL TRIAL, LEISHMANIA MAJOR, CUTANEOUS LEISHMANIASIS
 
 
References: 
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Citations: 
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APA: Copy

FIROUZ, A., & KHATAMI, A., & KHAMESIPOUR, A., & NASIRI KASHANI, M., & NILFOROUSHZADEH, M., & BEHNIA, F., & PAZOUKI TOROUDI, H., & DOULATI, Y. (2004). A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY, 7(4), 209-218. https://www.sid.ir/en/journal/ViewPaper.aspx?id=48027



Vancouver: Copy

FIROUZ A.R., KHATAMI A.R., KHAMESIPOUR A., NASIRI KASHANI M., NILFOROUSHZADEH MOHAMMAD ALI, BEHNIA F., PAZOUKI TOROUDI H.R., DOULATI Y.. A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY. 2004 [cited 2021June16];7(4):209-218. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=48027



IEEE: Copy

FIROUZ, A., KHATAMI, A., KHAMESIPOUR, A., NASIRI KASHANI, M., NILFOROUSHZADEH, M., BEHNIA, F., PAZOUKI TOROUDI, H., DOULATI, Y., 2004. A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY, [online] 7(4), pp.209-218. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=48027.



 
 
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