ω-3 PUFAS ARE EFFECTIVE AGAINST WEIGHT LOSS IN CACHECTIC CANCER PATIENTS

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MAHLUJI S.

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Journal Paper

Paper Information

Journal: Nutrition and food in health and disease Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 180-181

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Title

ω-3 PUFAS ARE EFFECTIVE AGAINST WEIGHT LOSS IN CACHECTIC CANCER PATIENTS

Author(s)

MAHLUJI S.

Keywords

ω-3 PUFAS

CACHEXIA

CANCER

WEIGHT LOSS

NF-KB

Abstract

Background: Unintentional WEIGHT LOSS (Cachexia) is a common symptom experienced by people with advanced progressive illness especially patients with CANCER and can be of great concern to those affected and of even greater concern to caregivers. The treatment approaches for decreasing WEIGHT LOSS are pharmacological treatments including anabolic steroids and megestrol acetate and non pharmacological interventions including nutritional support such as eicosapentaenoic acid (EPA), progressive resistive exercise and aerobic exercise. The current review focuses particularly on protective effects of EPA on CACHEXIA and its mechanisms.Methods: The PubMed and Science Direct were systematically searched to review epidemiological and review articles published from 2002- 2013.Results: w-3 polyunsaturated fatty acids (PUFAs), specifically eicosapentaenoic acid (EPA), have been shown to reduce the development of CACHEXIA in animal models with retention of both fat and muscle protein. EPA has been shown to decrease the production and action of a lipolytic factor, zinc-a2-glycoprotein (ZAG), involved in loss of adipose tissue in cachectic patients. EPA also conserves skeletal muscle in CACHEXIA by reducing the increased protein degradation, without any effects on the depression of protein synthesis.The effect on protein degradation is related to down regulation of the increased expression and activity of the ubiquitin-proteasome proteolytic pathway by preventing nuclear binding of the transcription factor nuclear factor-kB (NF-kB). Clinical studies also confirm the ability of w-3 PUFAs particularly EPA to reduce WEIGHT LOSS in cachectic CANCER patients with resulting in weight stabilization. However, when it used in combination with a high calorie and high nutritional supplement of protein, weight gain was obtained, although this outcome was not consensus between all large-scale placebo-controlled trials.Conclusion: This finding suggest that w-3 PUFAs particularly EPA could be effective in managing CACHEXIA, however further clinical studies are warranted to confirm that and whether it is equally effective in the treatment of CACHEXIA in different types of CANCER.

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APA: Copy

MAHLUJI, S.. (2014). ω-3 PUFAS ARE EFFECTIVE AGAINST WEIGHT LOSS IN CACHECTIC CANCER PATIENTS. NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 180-181. SID. https://sid.ir/paper/342609/en

Vancouver: Copy

MAHLUJI S.. ω-3 PUFAS ARE EFFECTIVE AGAINST WEIGHT LOSS IN CACHECTIC CANCER PATIENTS. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):180-181. Available from: https://sid.ir/paper/342609/en

IEEE: Copy

S. MAHLUJI, “ω-3 PUFAS ARE EFFECTIVE AGAINST WEIGHT LOSS IN CACHECTIC CANCER PATIENTS,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 180–181, 2014, [Online]. Available: https://sid.ir/paper/342609/en

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