Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   March 2006 , Volume 31 , Number 1; Page(s) 22 To 27.
 
Paper: 

SEDATIVE-HYPNOTIC ACTIVITY OF EXTRACTS AND ESSENTIAL OIL OF CORIANDER SEEDS

 
 
Author(s):  EMAM GHOREYSHI M.*, HEYDARI HAMEDANI G.
 
* DEPARTMENT OF PHARMACOLOGY SCHOOL OF MEDICINE SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Coriandrum sativum L. has been recommended for relief of insomnia in Iranian traditional medicine. However, no pharmacological studies have yet evaluated its sedative effects. The aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (100, 200, 400 and 600 mg/kg) were intraperitoneally administered to male albino mice, 30 minutes before pentobarbital injection (40 mg/kg). Latency to sleep and sleep duration were recorded.
Results: Aqueous extract prolonged pentobarbital-induced sleeping time at 200, 400 and 600 mg/kg. Hydro-alcoholic extract at doses of 400 and 600 mg/kg increased pentobarbital-induced sleeping time compared to saline-treated group. The essential oil increased pentobarbital-induced sleeping time only at 600 mg/kg.
Conclusion: The extracts and essential oil of coriander seeds possess sedative-hypnotic activity. However, it is strongly suggested that the major active component(s) responsible for the hypnotic effect is mainly present in the aqueous extract.

 
Keyword(s): CORIANDRUM SATIVUM, SEDATIVE, HYPNOTIC, EXTRACT, ESSENTIAL OIL, PENTOBARBITAL
 
References: 
    exThe server principal "sidrdro" is not able to access the database "admin_Host353" under the current security context.
 
  pdf-File tarjomyar Yearly Visit 273
 
Latest on Blog
Enter SID Blog