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Information Journal Paper

Title

ADVANCED GLYCATION END PRODUCT INHIBITORY EFFECT OF QUERCETIN-3-O-RUTINOSIDE, ISOLATED FROM TEUCRIUM POLIUM

Pages

  125-134

Keywords

ADVANCED GLYCATION END PRODUCTS (AGES) 

Abstract

 Background: Several mechanism including autoxidation of glucose, protein glycation and advanced glycation end products (AGEs) formation may to be involved in hyperglycemia mediated oxidative stress. Herein, in this study, the effects of RUTIN with high antioxidant activity isolated from TEUCRIUM POLIUM on structural changes of human serum albumin (HSA) were performed.Methods: The major compounds of T. polium methanol extract were isolated and their radical scavenging properties were established through various approaches including 1, 1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radicals scavenging, and reducing power. The structural changes of HSA with glucose, in the presence of RUTIN were studied with far-UV CD spectroscopy.Results: Based on our results, RUTIN, a flavonol glycoside isolated from T. polium exhibited high antioxidant activity compared to the other isolated compounds from T. polium. RUTIN inhibited high glucose induced oxidative damages to protein by decreasing protein carbonyl formation (PCO) and preventing thiols group from oxidation. In addition, evaluating the structural changes of HSA by glucose in the presence of RUTIN showed that RUTIN may be able to increase the helicity of the protein and prevent helix decrement in the secondary structure of HSA.Conclusion: We found that RUTIN with high antioxidant activity effectively inhibited the generation of amadori products and exhibited good inhibitory effects on the formations of α-dicarbonyl compounds and AGEs.

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    APA: Copy

    ESMAEILI, MOHAMMAD ALI. (2014). ADVANCED GLYCATION END PRODUCT INHIBITORY EFFECT OF QUERCETIN-3-O-RUTINOSIDE, ISOLATED FROM TEUCRIUM POLIUM. PHARMACEUTICAL SCIENCES, 19(4), 125-134. SID. https://sid.ir/paper/619055/en

    Vancouver: Copy

    ESMAEILI MOHAMMAD ALI. ADVANCED GLYCATION END PRODUCT INHIBITORY EFFECT OF QUERCETIN-3-O-RUTINOSIDE, ISOLATED FROM TEUCRIUM POLIUM. PHARMACEUTICAL SCIENCES[Internet]. 2014;19(4):125-134. Available from: https://sid.ir/paper/619055/en

    IEEE: Copy

    MOHAMMAD ALI ESMAEILI, “ADVANCED GLYCATION END PRODUCT INHIBITORY EFFECT OF QUERCETIN-3-O-RUTINOSIDE, ISOLATED FROM TEUCRIUM POLIUM,” PHARMACEUTICAL SCIENCES, vol. 19, no. 4, pp. 125–134, 2014, [Online]. Available: https://sid.ir/paper/619055/en

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