The aim of the present study was to examine the effects of eccentric contraction on hematological blood markers in non - athlete young man. Fourteen male non- athlete (age: 24.28±1.14 yrs, height: 1.75±0.48 m, weight: 73.14±5.43 kg, BMI: 23.42±1.06 kg/m2 and BF%: 14.71±1.35) volunteered in this study. Eccentric contraction was induced by 3 sets (15 repetition/set) by the intensity of 70% of lRM using hamstring curl weight machine. At baseline and after the intervention (immediately, 24 and 48h), subjects were submitted to a blood sample to determine their hematological profile (red blood cells, hemoglobin, hematocrit, platelets, leukocytes, neutrophils, lymphocytes, monocytes, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width). ANOVA for repeated measurements showed significant differences were effect on platelets, leukocytes, neutrophils, lymphocytes, monocytes, mean corpuscular volume immediately after exercise. However, no significant differences blood markers between 24 and 48 h after exercise (P³0.05). The results of this research showed that one season resistant training to eccentric contraction curse change leukocytes, PLT and MVC immediately exercise. Also insignificant changes in other variable, probabilities this chance because low volume muscle and kind of muscles contraction.