مشخصات

عنوان:

بررسی میزان بروز اختلالات تکامل عصبی در کودکان 1 تا 3 ساله مبتلا به کم کاری مادرزادی تیرویید تحت درمان با لووتیروکسین



گروه تخصصی:  پزشکی

سازمان مجری:  پژوهشکده علوم بهداشتی (گزارش طرح های دفتر مرکزی) 

گروه پژوهشی: ارتقای سلامت

پژوهشگران: 
مظفری کرمانی رامین (مسئول طرح)
احمدی احمد (همکار طرح)
صدیقی ژیلا (همکار طرح)
طاووسی محمود (همکار طرح)
حائری مهریزی علی اصغر (همکار طرح)
رستمی راحله (همکار طرح)

تاریخ خاتمه:  تیر 1397

کارفرما: 

خروجی طرح: 
 
تلفن: 66480804- 9-66951877-021

نشانی سازمان مجری: تهران، خیابان انقلاب، خیابان فلسطین جنوبی، خیابان شهید وحید نظری، پلاک 51، کدپستی: 1315795795، صندوق
 

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کلیدواژگان: کودکان,کم کاری تیرویید مادرزادی,تکامل عصبی,پرسشنامه سنین و مراحل ASQ

 
 
Title:

Neurodevelopment disorders incidence rate in 1-3 years old child's with congenital hypothyroidism under treatment with Levothyroxin



Abstract:

Congenital hypothyroidism is the most common preventative developmental disorder in infants and children, which if it not treated promptly, it leads to mental retardation and developmental abnormalities. The prognosis of the disease improves with the screening of congenital hypothyroidism in neonates and the administration of levothyroxine during this period. Despite the diagnostic screening and the initiating early treatment for neonates with congenital hypothyroidism, there are reports of high prevalence of neurodevelopmental disorders in these children. Considering the neurodevelopmental disorder outcomes in infants with congenital hypothyroidism and the frequency of administration of levothyroxine in the treatment of Iranian newborns and emphasizing early diagnosis of this disorder, this study was considered necessary. In a historical cohort study, 122 neonates with congenital hypothyroidism under treatment with levothyroxine and 122 healthy children aged between one and three years were evaluated by the ASQ questionnaire for their neurodevelopmental status. Sampling was done non-randomly. In the exposure group, questionnaires were asked by telephone or they were invited to the clinic for an assessment period after contact with them. In the healthy children group (control group), children who were referred to the clinic for periodic examinations were selected. Overall evaluation of developmental status in children with congenital hypothyroidism and healthy children was 17. 2% and 12. 3% of the children in development test did not score the quotient and had a relative risk of 1. 4, but this risk was in the 95% confidence level was not significant. In children with hypothyroidism, if the starting time of the drug is less than the age of one month, 11. 4% of the children have developmental disorder, and if the drug was started after one month, 32. 4% of the children had neurodevelopment disorder. The results of chi-square test showed significant differences. (X2 = 7/582 and Sig= 0/006. ). The study showed that children with congenital hypothyroidism will develop normal if diagnosis and initiation of treatment in children under the age of one month is started. If the diagnosis and treatment begins after one month, there is some degree of developmental delay in children. The prescribed dose of 10 micrograms per kilogram of baby weight at the start of treatment and adjusting the dosage of the drug correlate with the age of the child and continuing until the age of three, will lead to normal development in children.



Keyword(s): Children,Congenital Hypothyroidism,Neurodevelopment,Ages and Stages Questionnaire (ASQ)