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Paper Information

Journal:   SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL   FALL-SPRING 2004-2005 , Volume 8 , Number 9-10; Page(s) 35 To 43.
 
Paper: 

THE EFFECT OF ISOPROTERENOL ON WEIGHT AND CELL STRUCTURE OF CAT SUBMANDIBULAR SALIVARY GLAND

 
 
Author(s):  MOHAMMADPOUR AHMAD ALI*
 
* DEPARTMENT OF BASIC SCIENCES, SCHOOL OF VET. MED., SHAHREKORD UNIVERSITY, SHAHREKORD, IRAN
 
Abstract: 

In this research, to define side effects of isoproterenol or isoprenaline (a beta adrenergic drug) on weight and cell structure of cat submandibular gland, ten female adult cats were used. The animals were divided in two groups, control and treatment. Treatment group received daily intraperitoneal injections of 1.7 mg per animal isoproterenol dissolved in 5 ml of sterile distilled water for 20 days. The control group received 5 ml of sterile distilled water. In the end of the experiment both animal groups were anesthetized with Ketamin and authonized with overdose of Nesdonal. The left and right submandibular glands were dissected and were selected for histomorphological studies. Chronic treatment of isoprenaline with dosage of 1.7 mg per cat {range of b.w.2-2.5kg) for 20 days revealed remarkable changes on weight and cell structure of submandibular gland. In the treatment group, the mean weight of submandibular gland increased from 1388 mg to 1878 mg. It showed 1.35 folds in wet weight as compared to the control group. By statistical analysis using t-test between left and right glands, the weight changes of left submandibular gland were seen more than the right one and were statistically significant (P<0.05). Histological studies showed hypertrophy of secretory units with detectable of serous demilunes in treatment group.

 
Keyword(s): ISOPROTERENOL, SUBMANDIBULAR GLAND, HISTOLOGICALCHANGES, CAT
 
References: 
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