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Paper Information

Journal:   JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)   WINTER 2006 , Volume 15 , Number 58/1 (BIOLOGY); Page(s) 528 To 538.
 
Paper: 

EFFECT OF HISTAMINERGIC AND CHOLINERGIC SYSTEMS ON MEMORY RETENTION

 
 
Author(s):  EYDI A.*, EYDI M., ORYAN SHAHRBANOU, PARIVAR KAZEM
 
* BIOLOGY DEPARTMENT, SCIENCE AND RESEARCH CAMPUS, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

In the present study, the effects of the histamine and cholinergic systems on memory retention in adult male rats were investigated. Post-training intracerebroventricular injections were carried out in all the experiments. Cholinoceptor agonists, acetylcholine (1-10 mg/rat) or nicotine (1-10 mg/rat) increased, while a cholinoceptor antagonist, scopolamine (5-20 mg/rat), decreased memory retention. The response to acetylcholine was attenuated by scopolamine. Administration of histamine (5-20 mg/rat) reduced, but the histamine H1 receptor antagonist, pyrilamine (10-50 mg/rat), and the histamine H2 receptor antagonist, cimetidine (1-50 mg/rat) increased memory retention in rats. The histamine receptor antagonists attenuated the response to histamine. Histamine reduced the acetylcholine- or nicotine-induced enhancement. The histamine receptor antagonists enhanced the nicotine- or acetylcholine-induced response. Histamine potentiated the inhibitory effect induced by scopolamine. It is concluded that histaminergic and cholinergic systems have opposing effects on memory retention. Also, the histaminergic system elicits an interaction with the cholinergic system in memory retention.

 
Keyword(s): MEMORY RETENTION, PASSIVE AVOIDANCE, CHOLINOCEPTOR DRUG, HISTAMINERGIC AGENT, (RAT)
 
References: 
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