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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   FALL 2007 , Volume 14 , Number 56; Page(s) 91 To 99.
 
Paper: 

THE EFFICACY OF TRAMADOL 50 AND 100MG IN COMBINATION WITH 2% LIDOCAINE IN EPIDURAL ANESTHESIA FOR LOWER LIMB ORTHOPEDIC SURGERY

 
 
Author(s):  HASANI V.A.*, SAMARKHAH M., KHOSRAVI ZANJANI A.
 
* NIAYESH ST., SATTARKHAN AVE., HAZRAT-E-RASOOL AKRAM HOSPITAL, IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, TEHRAN, IRAN
 
Abstract: 
Background & Aim: Tramadol is an analgesic with combined opioid agonist and monoamine reuptake blocker properties, which may be useful as a perioperative analegesic and antinociceptive adjuvant. The aim of this study was to evaluate the efficacy of Tramadol 50 and 100 mg in combination with 2% Lidocaine in epidural anaesthesia for lower limb orthopedic surgery.
Patients and Methods: In this randomized, double-blind study, 50 patients undergoing lower extremity orthopedic surgery was enrolled. Patients were randomly assigned to receive either epidural 50 mg Tramadol + 2% Lidocaine (n=25) or 100 mg Tramadol + 2% Lidocaine(n=25). Level and duration of block, change of haemodynamic status and side-effects in each group were compared.
Results: There were no differences between the groups in regard to level and duration of analgesia, demographic characteristics and side effects (P>0.05). Although, systolic blood pressure was decreased significantly in both groups (P<0.05), it was not statistically significant.
Conclusion: We suggest that a combination of Tramadol with 2% lidocaine can provide effective and safe preoperative analgesia. Increasing the dose of Tramadol to l00mg, as compared to 50mg dose, does not significantly affect the efficacy and/or side effects.
 
Keyword(s): EPIDURAL ANALGESIA, LEVEL OF BLOCK, SIDE-EFFECT, TRAMADOL, DURATION OF ANALGESIA
 
References: 
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