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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   FALL 2005 , Volume 19 , Number 3; Page(s) 251 To 254.
 
Paper: 

SYNERGISM BETWEEN 1-MEGAHERTZ THERAPEUTIC ULTRASOUND PLUS CEFTAZIDIME ON GROWTH OF PSEUDOMONAS AERUGINOSA

 
 
Author(s):  KASHEF N.*, BEHZADIANNEZHAD GH., SATARI MORTEZA, MOKHTARI DIZAJI M.
 
* DEPARTMENT OF BACTERIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 
Objective: The effect of ceftazidime on Pseudomonas aernginosa, with or without application of 1MHz therapeutic ultrasound, was studied.
Method: An aqueous suspension of microorganisms in a sterile, sealed plate was placed in an ultrasonic tank operating at 1MHz. Different power outputs were used. After desired time of exposure to the ultrasound, each sample was plated separately and after incubation, the number of colonies was counted.
Results: Results showed that ultrasound in combination with sMICs of ceftazidime was much more lethal to this bacterium than either of the treatments alone. The mechanism by which ultrasound enhances antibiotic action is due to the induction of uptake of antibiotic by perturbing or stressing the membrane.
Conclusion: This application of ultrasound may be useful for expanding the number of drugs available for treating localized infections by rendering bacteria susceptible to normally ineffective antibiotics.
 
Keyword(s): CEFTAZIDIME, PSEUDOMONAS AERUGINOSA, ULTRASOUND
 
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