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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   SPRING 2007 , Volume 14 , Number 1 (SN 43); Page(s) 56 To 62.
 
Paper: 

EVALUATION OF CIPROFLOXACIN CYTOTOXIC EFFECT IN RAT TESTIS

 
 
Author(s):  KHAKI AMIR AFSHIN*, HEYDARI M., GHAFARI NOVIN M., KHAKI A.A., REJAIE F.
 
* DEPARTMENT OF VETERINARY PATHOLOGY, SCHOOL OF VET. MED., ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

Introduction & Objective: Ciprofloxacin is a synthetic antibacterial agent belonging to the family of fluoroquinolones with a very broad spectrum against microbial pathogens, especially Gram-negative infectious diseases, that has been approved in more than 100 countries world-wide. The aim of this study was to see histopathological and cytotoxic effects of ciprofloxacin after inducement in rat testis.
Materials & Methods: The twenty male wistar rat were selected and randomly divided into two groups; control (n=10) and test (n=10). The test group was received 12.5mg/kg (PO) ciprofloxacin daily for sixty day; however the control group just received plate. On sixtieth day the testis tissue of rat in both groups were removed and were prepared for light microscopy and cytotoxic studies.
Results: Study about cytotoxic effects was indicated that absorption of radiation rate after five day in control group was increased when as compared with experimental group, (Control: 92.8±1.5 & Test: 65±6, P<0.05) and the studies of testis tissue slices of test group showed many changes such as necrosis in spermatocyt I cells plus diameter of nuclei in spermatocyt I, was increased, (P<0.01).
Conclusion: Since in our study ciprofloxacin had cytotoxic side effect on spermatocyt I cells, and rate of cell death may be increased in this cells then consequently ciprofloxacin inducement is harmful for sperm health ability parameters and due decrease fertility rates in human.

 
Keyword(s): CIPROFLOXACIN, CYTOTOXICITY, RAT, TESTIS
 
References: 
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