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Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   DECEMBER- JANUARY 2006-2007 , Volume 8 , Number 6 (34); Page(s) 20 To 24.
 
Paper: 

COMPARISON OF ITRACONAZOLE AND CLOTRIMAZOLE IN TREATMENT OF VULVO VAGINAL CANDIDASIS

 
 
Author(s):  NAZARI TAHEREH*, ZEYNALZADEH MAHTAB, HAMEDI MAHDIS, RIAZI G., HAJIAN KARIM, SEFIDGAR S.A.A.
 
* BABOL UNIV. MEDICAL SCIENCES
 
Abstract: 

BACKGROUND& OBJECTIVE: Considering the high prevalence of vaginal candidiasis and its complications, selection of the best medical treatment based on clinical and microscopic findings, decrease of recurrence rate, short term of therapy with oral agents is so important. The aim of this study was to compare a 3-day course of oral itraconazole versus 7-day course of vaginal clotrimazole for the treatment of vulvo vaginal candidiasis.
METHODS: This study was performed on 100 women with clinical and mycological diagnosis of vaginal candidisis who referred to Babol Yahyanejad hospital during one year. They were randomly divided into two groups, those who were treated with vaginal clotrimazole (100 mg/daily for 7 days) and those treated with oral itraconazole (200mgldaily for 3 days). All were followed for 14 and 45 days after treatment. The results of treatment and recurrence rate were recorded.
FINDINGS: In clotrimazole regimen, 36 (72%) patients were cured clinically and 30 (6%) patients were cured microscopically. In itraconazole regimen, 39 (78%) cases were cured clinically and 35 (70%) patients were cured microscopically. Twenty nine cases did not complete the treatment (16 cases of itraconazole and 13 of clotrimazole group). In clotrimazole group, clinical and microscopical recurrence rate was 41.2% and 61.8%, respectively. In itraconazole group, clinical and microscopical recurrence rate was 35.1% and 48.6%, respectively (p>0.05). There was not seen any intolerance in both agents.
CONCLUSION: According to the results, both oral itraconazole and vaginal clotrimazole has similar effect in the treatment of vaginal candidiasis. Although, clinical and microscopical improvement and recurrence were a little better in itraconazole group.

 
Keyword(s): CANDIDIASIS, CLOTRIMAZOLE, INTRACONAZOLE, VAGINITIS
 
References: 
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