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Paper Information

Journal:   IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY   FALL-WINTER 2006-2007 , Volume 9 , Number 2; Page(s) 11 To 16.
 
Paper: 

COMPARISON OF THE EFFECTS OF METFORMIN AND CYPROTERONE COMPOUND ON SERUM ANDROGENS AND C - REACTIVE PROTEIN IN PATIENTS WITH P.C.O.S

 
 
Author(s):  AGHA MOHAMMADZADEH N.*, BEGLER L., ABD ELAHIFARD S., BAHRAMI A., MOSHREBI O.
 
* 
 
Abstract: 

Introduction: polycystic ovary syndrome is one of the most common endocrine disorders in women at reproductive age. Characteristics of this syndrome are menstrual irregularities with clinical or laboratory evidence of androgen excess. This syndrome increases the risk of infertility, type 2 diabetes, dyslipidemia and cardiovascular diseases, and it has recently been showed that the cause of increased risk of cardiovascular diseases is low grade chronic inflammation which can be evaluated by measuring high sensitive C-reactive protein. The aim of this study is to compare the effects of metformin and cyproterone compound on serum androgen and CRP levels.
Material and methods: in a clinical trial study during a period of 16 mouths from December 2004 to March 2006, sixty patients with PCOS were enrolled, 30 subjects in each group treated with one gram of metformin and cyproterone compound for 21 days, every month. At the beginning and after 3 and 6 months, weight, height, testosterone, DHEA-S and Hs-CRP levels were measured.
Result: mean age of patients was 23.5±8.7 years with the range of 15 to 49 years. In both groups a significant decrease in DHEA-S levels was observed. In compound group, after six mounts a significant decrease in testosterone levels were seen, but there was no significant decrease in Hs-CRP levels.
Comparison of two groups showed that there were no significant differences in the effects of these two drugs on serum testosterone, DHEA-S and Hs-CRP levels.
Conclusion: the results of this study are different from those of previous studies about beneficial effects of meformin of Hs-CRP levels.

 
Keyword(s): PCOS, METORMIN, CYPROTERONE COMPOUND, HS-CRP
 
References: 
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