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Paper Information

Journal:   HAKIM RESEARCH JOURNAL   FALL 2002 , Volume 5 , Number 3; Page(s) 213 To 217.
 
Paper: 

CHANGES OF THE IMMUNE SYSTEM IN MALE ATHLETES AFTER A HEAVY ATHLETIC ACTIVITY

 
 
Author(s):  MIRSHAFIEI A., SARRAFNEJAD A., EBRAHIM KH., GHARAKHANLOU R., AMIR SASAN R., MEMARI A.M., KHOSRAVI F.
 
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Abstract: 

The present research studies changes resulting from regular and continues exercises as well as the effect of a heavy aerobic activity on the immune system of athletes.
In this investigation 15 professional athletes from different sports clubs and universities along with 15 non-athlete students whom were matched for sex, age, weight and height were selected. Each individual completed a special questionnaire to be healthy during the study period. Their immune status was evaluated by assessment of the following parameters: WBC differential for lymphocytes, neutrophils, monocytes and eosinophils. Immunophenotyping by flow cytometry was performed using the following markers: CD3 for T-cell, CD19 for B-cell, CD14 for monocyte, CD56 for NK-cell, CD45 for leuckocyte, CD4 for T-h, CD8 for T-s/c & CD4/CD8 ratio. Also IgG was determined by SRID (single radial immunodiffusion).
The statistical community of this research was Tehran University. The proposed activity, a heavy aerobic exercise activity (Bruce protocol), was carried out on a treadmill and continued until the border of incapability. A sample of 10ml blood was obtained from each individual of non-athletes group at rest position between 8:30-9:00 am. The athletes group were also bleeded the same volume, and at the same time (30 minutes before starting Bruce test), and then, the second blood sample (10ml) was obtained from each athlete, immediately after the test. Blood samples were sent to immunogenetic laboratory for flow cytometry, hematology and immunoglobulin assay test.
Results revealed that a heavy aerobic activity can decrease the amount of IgG and increase the number of NK cells (CD56) following Bruce treadmil test in professional athletes compared with non-athletes. Also, a significant increase of CD4 and CD8 cells was observed in athletes group.

 

 
Keyword(s): IMMUNE SYSTEM, ATHELET, HEAVY AEROBIC ACTIVITY
 
References: 
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