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Paper Information

Journal:   JOURNAL OF MARINE SCIENCES AND TECHNOLOGY   Fall 2003 , Volume 2 , Number 4; Page(s) 71 To 80.
 
Paper: 

EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS

 
 
Author(s):  KARIMZADEH K., MOSTAFAIE A., ESMAEILI SARI A.*, POURKAZEMI MOHAMMAD, ZAHMATKESH A.
 
* Dept. of Environment Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Noar, Iran
 
Abstract: 

The microsomal cytochrome P450 dependent mixed function oxidase systemes is responsible to catalyze the first step of chemical Biotransformation. In this research the inducing effects of 3- Methyl Cholantheren were studied in Acipenser persicus microsomal mixed function oxidase. Fish were received 3- MethylCholantheren at doses about 20 and 40 mg/kg body weight/day i.p.for 3days respectively. In treatment fish did not observe any significant changes in anilin 4 –hydroxylase and NADPH - cytochrome C reductase, but 3 - Methylcholantheren treatment caused a 20 - 25 fold increase in 7 - Ethoxyresorufin- O-deethylase (EROD) activity of fish liver microsome.
Acipenser persicus liver microsomal EROD activity was investigated with respect to substrate concentation, amount of enzyme, incubation period and temperature.
 SOS -PAGE of microsomal protein pattern was showed that there is a protein with molecular mass of 58±1 KDa. So induction effect of 3 -Methylcholantheren could be induced isoenzyme P4501A. and is increased the isoenzyme biosynthysis.

 
Keyword(s): MIXED FUNCTION OXIDASE, ETHOXYRESORUFIN-O DEETHYLASE(EROO), CYTOCHROME P4501A, ACIPENSER PERSICUS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

KARIMZADEH, K., & MOSTAFAIE, A., & ESMAEILI SARI, A., & POURKAZEMI, M., & ZAHMATKESH, A. (2003). EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS. JOURNAL OF MARINE SCIENCES AND TECHNOLOGY, 2(4), 71-80. https://www.sid.ir/en/journal/ViewPaper.aspx?id=55165



Vancouver: Copy

KARIMZADEH K., MOSTAFAIE A., ESMAEILI SARI A., POURKAZEMI MOHAMMAD, ZAHMATKESH A.. EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS. JOURNAL OF MARINE SCIENCES AND TECHNOLOGY. 2003 [cited 2021October27];2(4):71-80. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=55165



IEEE: Copy

KARIMZADEH, K., MOSTAFAIE, A., ESMAEILI SARI, A., POURKAZEMI, M., ZAHMATKESH, A., 2003. EFFECTS OF 3 - METHYL CHOLANTHEREN ON LIVER MICROSOMAL MIXED FUNCTION OXIDASE ACTIVITIES OF ACIPENSER PERSICUS. JOURNAL OF MARINE SCIENCES AND TECHNOLOGY, [online] 2(4), pp.71-80. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=55165.



 
 
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