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Paper Information

Journal:   GOVARESH JOURNAL   July-October 2002 , Volume 7 , Number 37-38; Page(s) 38 To 44.
 
Paper: 

STUDY ON THE FREQUENCY OF HYPERAMYLASEMIA IN PATIENTS AFFECTED BY INFLAMMATORY BOWEL DISEASE AND ITS RELATIONSHIP WITH EXTENT AND ACTIVITY OF THE DISEASE

 
 
Author(s):  EBRAHIMI DARYANI N., FOROUTAN H., MAJIDI M., BAHRAMI H., HAGHPANAH BEHZAD, MIRMOUMEN SH., MOHAMADI H., NAYER HABIBI A.
 
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Abstract: 

Background: Serum Amylase elevation has been detected in some patients with inflammatory bowel diseases and recently some studies have elicited a relationship between amylase elevation and disease extent and activity.
Material and Methods: 212 patients (101 male and 100 female) with Inflammatory Bowel Disease (including 193 patients with UC and 19 patients with CD) whose diseases were confirmed by colonoscopy and histology were enrolled prospectively. Exclusion Criteria included: Pregnancy, CHF, Malignancy, Renal Failure, Diseases of Salivary Glands, Ruptured Peptic Ulcer, Peritonitis, and Cholecystitis. For all patients serum and urine amylase levels were measured and a detailed questionnaire was filled.
Results: Hyperamylasemia was observed in 16.0% of patients (15.5% of patients with UC and 21.0% of patients with CD). In 13.7% of patients (13.5% of UC patients and 15.8% of CD patients) urine amylase elevation was detected. There was no significant relationship between serum/urine amylase and disease extent, and activity, smoking habit, drug usage, extraintestinal involvement and history of colectomy. No significant association was found between serum amylase and extent or activity of CD, too. We found a significant relationship between urine amylase and activity, and not extent, of CD (p value: 0.005).
Conclusion: An increase of serum/urine amylase levels is seen in some of patients with inflammatory bowel disease; but the pathophysiology of this finding and its association with extent and activity of disease is open to further investigations.

 
Keyword(s): AMYLASE, IBD, DISEASE ACTIVITY
 
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