Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   OFOGH-E-DANESH   Winter 2005 , Volume 10 , Number 4; Page(s) 38 To 42.
 
Paper: 

EFFECTS OF ETHANOL ON PANCREATIC CELLS IN ADULT MICE

 
 
Author(s):  MOFIDPUR H., JAFARPOUR M., TABATABAEI YAZDI S.A., ALAVI S.A.A.F.
 
* 
 
Abstract: 

Background and Aim: Alcohol is a substance that its uncontrolled consumption has destructive effects on different organs of the body. Negative effects have investigated on esophagus, stomach, liver, heart, nervous system and some other organs. These investigations are continuous. Reports of pancreatic side effects of ethanol are scanty. This study was programmed for defining the destructive effects of ethanol on pancreatic cells.
Materials and Methods: In this interfered laboratory study 20 Balb/c male mice were selected and divided in two 10 members case and control groups randomly. 15 mg ethanol for each gram body weight intraperitonealy injected two times a day at 8Am and 4Pm. This process continued for 3 weeks. Control group received normal saline parallel and similar to case group. After 3 weeks, pancreas of all case and control groups' mice were removed and washed by normal saline. Then they were fixed by 10% formalin solution for 48 hours. Xylene and paraffin were used for defined periods of time. 5 micrometer thick sections were prepared by microtome. Prepared couples were stained by hematoxylin-eosin (H&E). So they were prepared for light microscopy.
Results: No changes were seen on exocrine and endocrine tissues of pancreas in control group. They had normal appearance. Local fatty changes in different area of both exocrine and endocrine parts of pancreas, as vacuoles in different sizes were seen in case group. Around the vessels and connective tissues inside the exocrine and endocrine parts, inflammation and dilated vessels with lymphocyte and plasmocytic infiltration were seen.
Conclusion: This study showed that ethanol can damages pancreas alike the liver, and produces steatose, acute pancreatitis, blockage the ducts by protein clots, fibrosis and chronic pancreatitis.

 
Keyword(s): PANCREAS, ETHANOL, MOUSE, PANCREATITIS, FATTY CHANGE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 64
 
Latest on Blog
Enter SID Blog