TWO MATRIX METALLOPROTEINASE INHIBITORS FROM SCROPHULARIA STRIATA BOISS

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MONSEF ESFAHANI HAMID REZA; SHAHVERDI AHMAD REZA; KHORRAMIZADEH MOHAMMAD REZA; AMINI MOHSEN; HAJIAGHAEE REZA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:1 Page(s): 149-155

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Title

TWO MATRIX METALLOPROTEINASE INHIBITORS FROM SCROPHULARIA STRIATA BOISS

Author(s)

Keywords

SCROPHULARIA STRIATA

NEPITRIN

ACTEOSIDE

WEHI-164

ZYMOANALYSIS

MMPS

Abstract

Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations.The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the SCROPHULARIA STRIATA extract by bio-guide fractionation.The aerial parts of S. striata were collected and different extracts were sequentially prepared with increasingly polar solvents. The MMPS inhibitory activity of the crude extract and its fractions were evaluated by the ZYMOANALYSIS method. The pure compounds were purified from the active fraction by chromatography methods. Chemical structures were deduced by nuclear magnetic resonance and mass spectrometry.Two active compounds (acteoside and NEPITRIN) were identified by bio-guide fractionation. The inhibitory effects of NEPITRIN and ACTEOSIDE at 20 mg/mL were about 56 and 18 percent, respectivly. The inhibitory effects of ACTEOSIDE at 80 mg/mL were increased to about 73 percent. In summary, the results suggest that NEPITRIN effectively inhibited MMPS inhibitory activity at low concentrations, whereas ACTEOSIDE showed inhibition at high concentrations.

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APA: Copy

MONSEF ESFAHANI, HAMID REZA, SHAHVERDI, AHMAD REZA, KHORRAMIZADEH, MOHAMMAD REZA, HAJIAGHAEE, REZA, & AMINI, MOHSEN. (2014). TWO MATRIX METALLOPROTEINASE INHIBITORS FROM SCROPHULARIA STRIATA BOISS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(1), 149-155. SID. https://sid.ir/paper/288364/en

Vancouver: Copy

MONSEF ESFAHANI HAMID REZA, SHAHVERDI AHMAD REZA, KHORRAMIZADEH MOHAMMAD REZA, HAJIAGHAEE REZA, AMINI MOHSEN. TWO MATRIX METALLOPROTEINASE INHIBITORS FROM SCROPHULARIA STRIATA BOISS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(1):149-155. Available from: https://sid.ir/paper/288364/en

IEEE: Copy

HAMID REZA MONSEF ESFAHANI, AHMAD REZA SHAHVERDI, MOHAMMAD REZA KHORRAMIZADEH, REZA HAJIAGHAEE, and MOHSEN AMINI, “TWO MATRIX METALLOPROTEINASE INHIBITORS FROM SCROPHULARIA STRIATA BOISS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 1, pp. 149–155, 2014, [Online]. Available: https://sid.ir/paper/288364/en

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