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Paper Information

Journal:   KOOMESH   Fall 2000 , Volume 2 , Number 1; Page(s) 17 To 24.
 
Paper: 

THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE

 
 
Author(s):  MOGHADAMNIA ALI AKBAR*, AFRAZ E.
 
* DEPT. OF PHARMACOLOGY, FACULTY OF MEDICINE, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
 
Abstract: 

Introduction: Black pepper is usually used in Iranian traditional medicine as a palliative agent. The aim of this study was to investigate the effect of piperine, an effective agent in black pepper, on pain sensitivity and also jumping induced by naloxone in morphine dependent mice.

Materials and Methods: This randomized experimental study was performed on mice. The animals divided into control (saline) and test (drug) groups. Morphine was used to produce drug dependency by Marshall method. Tail-flick test was used for evaluation of analgesic effect of the drug. Jumping method was used for measuring intensity of morphine dependency.

Results: The results show that different doses of piperine alone did not any significant effect on the tail-flick latency, but pretreatment of piperine (25, 50,75 mg/kg) significantly potentiated the analgesic effect of morphine (10 mg/kg) on the 'tail-flick la tency (P < 0.05). Pretreatment of piperine (25, 50, 75 mg/kg) significantly increased that the counts and latency of jumping in morphine-dependent mice in any tested dose, except for dose of 25 mg/kg of piperine which had no effect on jumping latency.

Conclusion: The data indicate that piperine itself has no any effect on analgesia and jumping, but potentiated the effect of morphine on the tail-flick latency and also affected morphine dependency.

 

 

 

 
Keyword(s): BLACK PEPPER, PIPERINE, MORPHINE, DEPENDENCY, ANALGESIA
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 88
 
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