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Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   June 2006 , Volume 5 , Number 2; Page(s) 63 To 67.
 
Paper: 

ACETAMINOPHEN USE AND THE SYMPTOMS OF ASTHMA, ALLERGIC RHINITIS AND ECZEMA IN CHILDREN

 
 
Author(s):  KARIMI M.*, MIRZAEI MASOUD, AHMADIEH M.H.
 
* Department of Pediatrics, School of Medicine, Shahid Sadoughi University Of Medical Sciences & Health Services,University Of Medical Sciences & Health Services,Yazd, Iran
 
Abstract: 

Allergic diseases are frequent in children and their prevalence and severity differ in the different regions of the world. A number of studies have been performed to determine the factors which are effective in the incidence of these diseases. One of the drugs that might have a role in incidence or intensity of the symptoms of allergic diseases is Acetaminophen. In our survey conducted with standardized method (International Study of Asthma and Allergies in Childhood), 3000 children 6-7 years old and 3000 teenagers 13-14 years old were questioned regarding asthma, allergic rhinitis and eczema. The prevalence of ever wheezing in the children of 6-7 years old who took acetaminophen in the first year of their life was 11.3%, which is more than other group (Odds Ratio=1.54, 95% Confidence Interval: 1-2.38, P=0.049) and the prevalence of ever wheezing in older age group who have taken acetaminophen at least once in a month was 25.1% which is more than those taken less acetaminophen (OR=1.7, 95% CI=1.43-2.04, P=0.000). Moreover taking more acetaminophen during past 12 months led to more prevalence of night dry coughs and the symptoms of rhinitis in children 6-7 years old and eczema and rhinitis symptoms in the 13-14 years old. Our findings suggest that taking more acetaminophen may be associated with increasing allergic symptoms in children.

 
Keyword(s): ACETAMINOPHEN, ALLERGIC RHINITIS, ASTHMA, ECZEMA
 
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