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Paper Information

Journal:   NUTRITION AND FOOD SCIENCES RESEARCH   NOVEMBER-DECEMBER 2014 , Volume 1 , Number SUPPL. (1); Page(s) 188 To 189.
 
Paper: 

THE EFFECT OF COENZYME Q10 SUPPLEMENTATION ON BLOOD PRESSURE, INFLAMMATION, AND LIPID PROFILE IN TYPE 2 DIABETES

 
 
Author(s):  MAZLOOM Z., MOAZEN M., DABBAGHMANESH M.H., AHMADI A.
 
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Abstract: 

Background: Diabetes is considered as a metabolic disorder associated with inflammation. Coenzyme Q10 (CoQ10) is a lipophilic substance that has recently been regarded as an anti-inflammatory compound. The current study evaluated the effect of CoQ10 supplementation on blood pressure, inflammation, and lipid profile in type 2 diabetics.
Methods: Fifty two patients with type 2 diabetes were involved in a randomized, single-blind, placebo-controlled clinical trial. The participants were randomly allocated to two groups: one group received CoQ10 supplements (100 mg twice a day) while the other received two placebos for 8 weeks. Systolic and diastolic blood pressures were determined for each of the participants before and after the study. Blood samples were collected at baseline and at the end of the intervention following an overnight fast. These were analyzed for an inflammatory marker (hs-CRP) and lipid profile (triglyceride, total cholesterol, LDL-C and HDL-C).
Independent and paired t-tests were performed to make statistical comparisons between and within the groups Results: CoQ10 supplementation resulted in a significant reduction in systolic blood pressure compared to the control group (p=0.001). Moreover, a comparison of the parameters within groups indicated that systolic blood pressure de-creased in the CoQ10 group (p < 0.001) and hs-CRP increased in the placebo group (p = 0.03). However, no changes were observed for lipid profile within or between the groups.
Conclusion: CoQ10 supplementation may decrease systolic blood pressure in type 2 diabetics and may prevent the elevation of inflammation in this group of patients. However it may not have any effects on lipid profile of diabetics.

 
Keyword(s): COENZYME Q10, DIABETES MELLITUS, BLOOD PRESSURE, INFLAMMATION, LIPID PROFILE
 
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