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Paper Information

Journal:   NUTRITION AND FOOD SCIENCES RESEARCH   NOVEMBER-DECEMBER 2014 , Volume 1 , Number SUPPL. (1); Page(s) 183 To 183.
 
Paper: 

ASSESMENT OF CHANGES IN LYNOHOCYTE SUBGROUPS DURING WEIGHT LOSS

 
 
Author(s):  MEHRDAD M.*, NOROUZI A.B., SAFARIAN M., NEMATI M., GANJALI N., SAFARIAN M.
 
* MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Background: To study the effect of weight loss program on plasma count of important lymphocyte subtypes (CD3, CD4, CD8, CD19, CD16/56) in obese premenopausal females and comparison to the control group.
Methods: In a randomized controlled trial, 29 non-pregnant, non-lactating, healthy obese females with BMI ? 30 were enrolled. Body composition, serum zinc and iron status and plasma count of lymphocyte subpopulations were measured, at baseline and at the end of the intervention.
Case group received a low calorie diet (3976.7 kJ/ 950 kcal per day) plus Lipase inhibitor (Orlistat: 120 mg per dose), soluble fiber (5g per dose), and daily moderate physical activity (VO2max 60%), until 10-15% weight loss. Data were analyzed and compared between case and control groups.
Results: After weight loss program Natural killer cells (CD16.56) and CD3 T-lymphocytes decreased significantly among case participants (p=0.02 and 0.001 respectively), but there was no significant changes in other immune markers.
Serum zinc and iron decreased significantly among case group as well (p<0.001 and p=0.03 respectively). Decrease in CD16.56 was correlated with BMI, weight, fat mass and trunk fat changes during weight loss.
Conclusions: Current findings suggest that weight loss program even with a balanced but calorie restricted diet together with daily moderate physical activity, might adversely affect immune system. Therefore, energy restriction could be an independent factor that affects some aspects of immunity. Further clinical trials based on other weight loss programs and evaluating other immune system markers might better identify the relation between weight loss and immunity.

 
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