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Paper Information

Journal:   IRANIAN JOURNAL OF IMMUNOLOGY (IJI)   SPRING 2006 , Volume 3 , Number 2; Page(s) 66 To 69.
 
Paper: 

ANTI-STREPTOKINASE ANTIBODY DETECTION BEFORE AND IMMEDIATELY AFTER STREPTOKINASE THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION

 
 
Author(s):  SHEMIRANI H., REZAEI A.*
 
* Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
 
Abstract: 

Background: Myocardial infarction is one of the most common and serious diseases resulting from coronary artery occlusion (obstruction) and major reduction in blood flow which occurs following rupture of atherosclerotic plaque or narrowing of coronary arteries. Streptokinase as a thrombolytic is considered the first and most important therapeutic intervention for reperfusion following myocardial infarction (MI) in most countries including Iran. Our previous study showed that, the prevalence of high antibody titers against streptokinase was 13.5% in the studied population from Iran, which was 2.5 times more common than data from other studies.
Objective: To evaluate anti-streptokinase antibody titers before and
immediately after streptokinase administration and its relation to reperfusion therapy success rates.
Methods: A total of 200 patients with acute myocardial infarction were
selected. Antibodies against streptokinase were measured before and 2 days after administration of streptokinase. At admission, before streptokinase administration and every hour after streptokinase administration, for 3 consecutive hours, an ECG was taken from each participant and the changes were evaluated in relation to antibody levels.
Results: Out of 200 patients, 42 (21%) had high levels of antibody
titer. Out of these 42 patients, 13 (6.5%) still had measurable levels of antistreptokinase antibody after streptokinase administration.
Conclusion: With respect
to the importance of reperfusion in acute myocardial infarction, our results show the ability of the anti-streptokinase antibody to neutralize effects of streptokinase. Hence, measurement of the serum levels of anti-streptokinase antibody is recommended before streptokinase administration.

 

 

 
Keyword(s): STREPTOKINASE, ANTI STREPTOKINASE ANTIBODY, MYOCARDIAL INFARCTION
 
References: 
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