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Paper Information

Journal:   THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)   Winter 2006 , Volume 2 , Number 7 (Special Issue); Page(s) 385 To 389.
 
Paper: 

COMPARISON OF CELL COUNTER INDICES IN DIFFERENTIATION OF BETA THALASSEMIA MINOR FROM IRON DEFICIENCY ANEMIA

 
 
Author(s):  GHAFOURI M.*, MOSTAAN SEFAT L., SHARIFI SH., HOSSEINI GOUHARI L., ATAR CHI Z.
 
* Quality Contorl Section, Tehran Regional Blood Transfusion Center No. 189, Vesal Avenu,Tehran, Iran
 
Abstract: 
Background and Objectives
Distinguishing two common hypochromic microcytic anemias (i.e. iron deficiency anemia and minor thalassemia) needs expensive laboratory tests not readily available everywhere. A number of indices derived from original cell counter parameters were tried to screen patients; these indices are compared in this study.

Materials and Methods

Four indices of England, Mentzer, Shine and MDHL were calculated for 110 cases of known thalassemia minors and 61 iron deficients. The best cut-off point for each index was selected by receiver operator characteristic (ROC) analysis reaching the highest sensitivity to separate thalassemics from iron deficients. Sensitivity and specificity of indices were compared.

Results

Mentzer’s index(sensitivity:90.9, specificity:80.3) had the best results.

Conclusions

It seems Mentzer’s index can be used widely to screen hypochromic microcytic anemic patients.Tests like hemoglobin electrophoresis, genetic studies, serum iron, TIBC and ferritin measurement should be reserved for selected patients in refferal centers. In this way we reduce public health costs significantly.
 
Keyword(s): DIFFERENTIAL DIAGNOSIS, MINOR THALASSEMIA, IRON DEFICIENCY
 
References: 
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  Persian Abstract Yearly Visit 91
 
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