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Paper Information

Journal:   JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES   Summer 2000 , Volume 7 , Number 3; Page(s) 137 To 144.
 
Paper: 

METABOLIC ACTIVATION AND DNA ADDUCT FORMATION OF BENZO (A) PYRENE BY ADULT AND NEWBORN RAT SKIN ANDLIVER MICROSOMES

 
 
Author(s):  MOHAMMADI QANATGHESTANI M., ALAMEH A.A., NOURI DALOUEI M.R.
 
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Abstract: 

Benzo (a) Pyrene is a carcinogen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic materials. Based on various epidemiological evidences it is related to lung, skin and liver cancer. Mutagen city, and immunosuppressivity are among important biological effects of Benzo (a) pyrene. After absorbtion and distribution in the body, it undergoes epoxidation by cytochrome P-450 system in the cells. Some of the electrophilic metabolites covalently bind to cellular macromolecules and in particular to DNA. Its metabolites are partially detoxified by conjunction to cellular glutathione (GSH), glucoronic acid, and sulphate. Biological effects of B (a) P and its metabolits depend on various factors such as species, age, sex, tissue, diet, dose, genetic system, etc. The fundamental physiological differences between newborns and adults are variations in susceptibility to chemical carcinogens observed between the two age groups. In this paper we studied the level of binding of B (a) P to calf thymus DNA and formation of DNA adduct in the incubation systems which contained adult and newborn rat liver and skin microsomes. Results indicate that in both age groups liver microsomes in comparison to skin microsomes cause a higher increase in the level of DNA adduct and the ratio of DNA adduct in the liver of adults compared to animal skin was 4.2 to 1. The quantity of adduct in the incubation systems containing liver microsomes of newborn was 1.51 higher than that of skin microsomes. Moreover phenobarbiton failed to induce cytochrome P-450 and any increase in DNA adduct level of B (a) P in the newborns rat. The level of cytochrome P-450 in adults liver was 2.86 times higher than that in newborns' liver.

 
Keyword(s): BENZO (A) PYRENE, DNA, NEWBORN, ADULT, PHENOBARBITON
 
References: 
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