Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS   2014 , Volume 3 , Number SUPPL. (1); Page(s) 32 To 32.
 
Paper: 

A COLLECTION OF BIOINFORMATICS TOOLS TO PROTEIN ENGINEERING

 
 
Author(s):  ARAB SEYED SHAHRIAR, SHIRVANIZADEH NILOOFAR, KHOSHNEJAT MARYAM
 
* 
 
Abstract: 

Protein engineering is an important tool for overcoming the limitations of natural enzymes as biocatalysts. In this regard computational tools are becoming increasingly important in order to create improved or novel enzymes. We developed a useful collection of bioinformatics tools in protein engineering. These applications are freely available at http: //bioinf.modares.ac.ir. A short description will come in the following: PUTracer is a useful and easy to use web based application to assign number of domains and domain boundaries in a protein. Recognition of domains in proteins is a critical step in chimeric protein engineering. LinDa (Linker Design Assistant) is a database of protein fragments in 4-20 amino acid length. Linda is an effective tool to chimeric protein engineering and peptide design. MPDB (Mutation Proposer on Disulfide Bond): Disulfide bonds formation is one of the solutions to increase the thermal stability of enzymes. MPDB gives a list of amino acids pair with potential to form a disulfide bond. CFinder (Contact Finder) Accurate identification of amino acids involved in the binding of the two proteins has wide applications, including antibody optimization, analysis of docking studies, increasing protein stability and peptide design. CFinder identifies amino acids involved in binding in a protein complex and also an individual amino acid neighbors too. Mini Mutate is a user friendly application to have the structure of a mutated protein. The input of application is native protein structure in PDB format and desired mutation. It will give the mutated protein structure after replacing amino acid and optimizing the structure.

 
Keyword(s): PROTEIN ENGINEERING, CHIMERIC PROTEIN ENGINEERING, PEPTIDE DESIGN, PROTEIN STABILITY, DOCKING ANALYSIS
 
References: 
  • ندارد
 
  Yearly Visit 133
 
Latest on Blog
Enter SID Blog