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Paper Information

Journal:   ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY   NOVEMBER 2014 , Volume 2 , Number SUPPLEMENT 1; Page(s) 59 To 59.
 
Paper: 

DEGREE OF MYOCARDIAL PERFUSION & FATTY ACID METABOLISM MISMATCH AND ITS CORRELATION WITH THE LV REMODELING FOLLOWING SUCCESSFULLY REPERFUSED ST SEGMENT ELEVATED MYOCARDIAL INFARCTION

 
 
Author(s):  BISWAS SHANKAR KUMAR, SARAI MASAYOSHI, TOYAMA HIROSHI, IWASE MASATSUGU, OZAKI YUKIO
 
* 
 
Abstract: 

Background: Discordant 123I?b?ethyl?odophenyl pentadecanoic acid (BMIPP) and 99mTc?tetrofosmin (TF) uptake is designated as viable dysfunctional myocardium. But a little is known about it’s relation with the left ventricular (LV) volume change / remodeling. This study was designed to unravel the impact of the degree of BMIPP?F mismatch and it’s correlation with change of LV volume following successfully reperfused ST?egment elevation myocardial infarction (STEMI).
Materials and Methods: Twenty five patients (Age: 60±11 yrs) with recent STEMI were enrolled, and all of them underwent emergency successful percutaneous coronary intervention (PCI). BMIPP and TF cardiac scintigraphy was performed on 7±3 days of admission. On 17 segment model, a difference of BMIPP and TF defect score by
³4 were considered as mismatched defect. Conventional echocardiography was performed within 24 hrs of admission, and at 3 months interval. Left ventricular end diastolic volume index (EDVI), and end systolic volume index (ESVI) were recorded accordingly.
Results: Out of 25 patients, 21 showed BMIPP
?TF mismatched defect and rest 4 showed matched defect.
Twelve patients (48%) showed reduction of left ventricular EDVI, and 14 (56%) patients showed reduction of ESVI over 3 months. Mismatched defect score showed a significant correlation with the relative change of EDVI (P=0.002, r=0.58) and ESVI (P=0.043, r=0.40).
Conclusion: The degree of dysfunctional viable myocardium showed nice correlation with the reduction of LV volumes following successfully reperfused STEMI, and emergency PCI could prevent the upcoming ventricular remodeling.

 
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