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Paper Information

Journal:   KOOMESH   Summer 2000 , Volume 1 , Number 3; Page(s) 17 To 24.
 
Paper: 

EFFECTS OF BASOLATERAL AND CENTRAL AMYGDALA LESIONS ON MODULATION OF SPATIAL MEMORY BY INTRAHIPPOCAMPAL INJECTIONS OF GLUCOCORTICOID AGONIST AND ANTAGONIST

 
 
Author(s):  VAFAEI A.A.*, BURES J., RASHIDIPOUR A., SHARIFI M.R.
 
* Dept. of Neurophysiology of Memory, Institute of Physiology, Prague, Czech Republic
 
Abstract: 

Introduction. The present experiment examined the effect of bilateral amygdala nuclei lesions on modulation of spatial memory storage induced by bilateral intrahippocampal micro infusions of glucocorticoid agonist and antagonist in male Long-Evans rats.
Material and Methods. Rats were surgically implanted bilaterally with cannulae aimed at the dorsal hippocampus were trained to avoid a 60 segment of the arena entering which was punished by mild foot shock. Place avoidance training occurred in a single 30-min session and the avoidance memory was assessed during a 30-min extinction trial 24 hours later. The time to the first entry and the numbers of entrances into the punished sector during extinction were used to measure the avoidance memory.
Results. Post-training infusions of the glucocorticoid receptor agonist (Dexamethason) enhanced spatial place avoidance memory retention and glucocorticoid receptor antagonist (RU-38486) impaired this task. In both tasks, neurochemically induced lesions of the basolateral but not of the central amygdala blocked the memory-modulated effects of the intrahippocampal infusions of the drugs affecting the glucocorticoid receptors.
Conclusion. These findings are consistent with previous evidence indicating that the lesions of the basolateral amygdala block the memory-modulatory effects of systemically administered glucocorticoids and provide further evidence that the basolateral amygdala is a critical area involved in regulating glucocorticoid effects in other brain regions involved in memory storage.

 
Keyword(s): GLUCOCORTICOID AGONIST, GLUCOCORTICOID ANTAGONIST, HIPPOCAMPUS, BASOLATERAL AMYGDALA, CENTRAL AMYGDALA, SPATIAL MEMORY, PLACE AVOIDANCE TASK
 
References: 
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