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Paper Information

Journal:   HAKIM RESEARCH JOURNAL   Spring 2004 , Volume 7 , Number 1; Page(s) 19 To 25.
 
Paper: 

RELATIONSHIP BETWEEN HORMONAL FACTORS AND BREAST CANCER

 
 
Author(s):  NOJOUMI MARZIEH, MIRFAKHRAEI R., HOSSEINI N.
 
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Abstract: 

Introduction: Breast cancer is the most common type of cancer among women of developing countries and the second one after lung cancer in developed countries except Japan. The incidence of this cancer is increasing in the world and knowing about its risk factors is necessary for preventing it. In Iran also there are some reports about increasing of incidence of the cancer as the first one between all type of cancers in1996. There are some studies about breast cancer and related factors, but with controversy, yet. The aim of this study was to determine the relation between some related hormonal factors and breast cancer.
Methods: This study performed between 1999 to 2001, with a hospital-based case-control study in Tehran and Mashhad. One hundred and fifty women with breast cancer and 430 women as control group recruited in the study. Non- probability convenience sampling was used for selection of the subjects. As related factors with breast cancer, oral contraceptive use and duration of usage, age in first complete pregnancy, total duration of breast feeding, history of incomplete pregnancy, age of menarche, and history of irregular menstruation are measured. We used Chi-square, t-test, and multiple logistic regression for analyzing data.
Results: The proportion oral contraceptive use history was 54.8 % in cases and 44.4 % in control group. About 39% of the women with breast cancer reported history of incomplete pregnancy and this proportion was 43.5 % in control group. Oral contraceptive use over 48 months was known as a risk factor for breast cancer (OR =2. 04, P=0.01). Total breast feeding more than 60 months had a protective role for breast cancer (OR=0.9, P=0.001). There were not any significant association between other variables (age at first pregnancy, irregular menstruation, age of menarche and incomplete pregnancy) and breast cancer.

Conclusion: This study showed a significant association between duration of oral contraceptive use, and total duration of breast feeding, and breast cancer.

 
Keyword(s): BREAST CANCER, RISK FACTORS, RELATED HORMONAL FACTORS
 
References: 
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  Persian Abstract Yearly Visit 86
 
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