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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   Winter 2001 , Volume 5 , Number 4; Page(s) 328 To 330.
 
Paper: 

EFFECT OF SODIUM-POTASSIUM INTAKE ON ARTERIAL STIFFNESS

 
 
Author(s):  GOLSHAHI J.*, MOBADI Z., ZAMANI N.
 
* Department of Internel Medicine, School of Medicine, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
 
Abstract: 

Introduction. Hypertension is one of the most common causes of cardiovascular problems in our society. Diet is the cheapest and the most accessible method of blood pressure (BP) control. BP is associated with arterial stiffness which affects cardiac afterload. This study evaluate the effect of diertary Na and K on vascular compliance.
Methods. We selected ninty six patients referred to Isfahan cardovascular Research center (affiliated to IUMSHS). Inclusion criteria were mild hypertension (90 <OBP< 99 mmHg and/or 140 <S.BP< 160 mmHg), age between 35-65 years old, body mass index (BMI) between 20-25, and no existing of any other chronic disease or medications. We divided samples into three equal diet group, randomly (A, B, G). The dietary content of sodium and potassium in each group was described as: moderate Na restriction + normal K content (group A), moderate Na restriction +high K content (group B), normal Na content + high K content (group G). Regimen was followed by each group for 16 weeks. Physical examination and anthropometric paramaters, lab data (e.g. FBS, Lipid profile, Uric acid, Serum Na & K, BUN, Gr and Ga), 24 hours urine sample for Na & K were compared before and after of intervention. In echocardiography the left ventricle dimensions and stroke volume were determined. Stroke volume: pulse pressure ratio was assumed as vascular compliance (1: arterial stiffness).
Results. Measured indicies were changed in groups as follow. Group A: Δ SBP = -8.43 mmHg; Δ DBP= -5.03 mmHg; Δ SV:PP= -0.28 ml/mmHg per beat (P> 0.05). Group B: Δ SBP= -0.82 mmHg; Δ OBP= -7.09 mmHg; Δ SV/PP= -0.22 ml/mmHg per beat (P> 0.05). Group G: Δ SBP=-7.22 mmHg; Δ OBP= -4.63 mmHg; Δ SV/PP= -0.01 ml/mmHg per beat (P>0.05).
Discussion. We recommend the above diets specially type B, as the first step in the treatment approach of mild HTN in our society. These dietary modifications didn't have any effect on arterial stiffness in 16 weeks of follow up. It is may be necessary to continue this intervention for changing arterial stiffness.
 

 
Keyword(s): DIET THERAPY, HYPERTENSION, ARTERIAL STIFFNESS, ELECTROLYTE, SODIUM, POTASSIUM
 
References: 
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