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Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   June 2002 , Volume - , Number 53; Page(s) 23 To 32.
 
Paper: 

EFFICACY OF INACTIVATED H9N2 AVIAN INFLUENZA VACCINE AGAINST NON-HIGHLY PATHOGENIC A/CHICKEN/IRAN/ZMT-173/1999 INFECTION

 
 
Author(s):  VASFI MARANDI M.*, BOZORG MEHRIFARD M.H., HASHEMZADEH M.
 
* FACULTY OF VETERINARY MEDICINE, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 

An experimental avian influenza (AI) oil-emulsion vaccine was formulated with a ratio of 4 parts oil adjuvant ISA-70 and 1 part formalin inactivated A/Chickne/Iran/ZMT-101(101)/98(H9N2) antigen. Thirty 2-week-old Aryan broilers and thirty 2-week-old white Hy-line pullets were vaccinated subcutaneously. The latter was delivered a booster 10 weeks after primary vaccination. All vaccinated and control birds were bled for hemagglutination-inhibition (HI) test at least one week intervals. Half of the birds were challenged via intranasal and intravenous routes with a h9N2 strain at 8 and 27 weeks of age in broiler and layer birds, respectively. High HI titers were observed in both vaccinated and unvaccinated birds, when examined at 2 weeks post-challenge (PC). Viral isolation or shedding from tracheal and cloacal swaps of both vaccinated broiler and layer was decreased at 2 weeks PC, as compared with unvaccinated control birds. All control birds became morbid, and egg production decreased on day 3 PC. The results suggested that the inactivated oil-emulsion H9N2 AI vaccine may be protects both chickens against viral shedding and egg drop in filed conditions.

 
Keyword(s): AVIAN INFLUENZA, OIL-EMULSION VACCINE, VACCINATION, BROILER, LAYER
 
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