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Paper Information

Journal:   IRANIAN JOURNAL OF DERMATOLOGY   Winter 2005 , Volume 8 , Number 2; Page(s) 97 To 100.
 
Paper: 

COMPARISON OF EFFICACY OF ORAL FLUCONAZOLE WITH INTRAMUSCULAR GLUCANTIME IN PATIENTS WITH ACUTE CUTANEOUS LEISHMANIASIS

 
 
Author(s):  FAMILI SOROUR ALZAMAN*, PEZESHKPOUR F.A.Z., SEPEHR V., VAHEDIAN MOHAMMAD
 
* Ghaem Hospital, Mashhad, Iran
 
Abstract: 
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Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues.
Objective: Comparison of the efficacy of fluconazole with systemic Glucantime in patients with acute cutaneous leishmanisis in Ghaem Hospital in Mashhad in 2002
Patients and Methods: During one year of study, all patients with cutaneous leishmaniasis were divided to two groups. Thirty-one patients were treated with oral fluconazole (100 mg twice a day) for 6 weeks and patients treated with 29 were intramuscular Glucantime (20 mgSb/kg) for 21 days. Both groups were evaluated 3 and 6 weeks after onset of treatment. "T" test and chi-square test were used for statistical analyses and P<0.05 was considered as significant.
Results: Six weeks after begining .of treatment, clinical cure, improvement and failure were observed in 4(12.9%) , 11 (35.5%) and 16(51.5%) of patients treated with fluconazole, respectively. These figures were 11(37.9%), 10(34.6%)and 8(21.5%) of patients treated with Glucantime, respectively (P>0.05).
Conclusion: It seems that efficacy of fluconazole in acute cutaneous leishmaniasis is lower than Glucantime. A larger clinical trial is recommended.
 
Keyword(s): CUTANEOUS LEISHMANIASIS,FLUCONAZOLE, GLUCANTIME
 
References: 
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