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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2004 , Volume 9 , Number 4 (40); Page(s) 231 To 236.
 
Paper: 

EFFECT OF HALFLY REPLACEMENT OF BREAKFAST'S BREAD WITH TWO LOW GLYCEMIC INDEX FOODS ON BLOOD GLUCOSE RESPONSE IN TYPE 2 DIABETES

 
 
Author(s):  MOFIDI A., TAHBAZ F., TALEBAN F.A.Z., VELAEI N.
 
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Abstract: 
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Background: There is no consensus about the effect of low glycemic index (LGI) foods in a mixed meal on glycemic response in type 2 diabetic patients. In this study therefore, we examined the effect of half replacement of bread in usual breakfast with apple or lentil on glycemic response in patients with type 2 diabetes.
Materials and methods: In a randomized cross-over clinical trial 18 diabetic patients who had fasting blood glucose between 126 to 180 mg/dl were studied. Patients received the modificated breakfast on 3 occasions with one-week interval. On the first day of the study, subjects ate their regular breakfast in usual amounts. Type and amount of the ingredients were recorded then. After one-week wash out period they were randomly divided into two groups, one had a breakfast in which half of bread replaced with apple and the other group received a breakfast in which half of bread was replaced with lentil. After one-week wash out period the diet switched between the 2 groups. Venous blood samples were collected before (after 12 hours fasting) and 60, 120, and 180 minutes after the breakfasts. Plasma glucose measured using enzymatic method (glucose oxidase) and incremental area under the 3 hours glycemic response curve were calculated. The data were statistically analyzed by paired t-test. P<0.05 was considered as significant.
Results: Sixteen patients (13 female and 3 male) aged 49.8±6.2 years (42 to 63 years) with diabetes duration of 5.6±5.1 years participated in this study. Regular breakfast items included tea, bread, cheese, tomato and cucumber. There were no significant differences between the compositions of regular breakfast with the two modificated breakfasts except for dietary fiber, which was significantly higher in two modificated breakfasts compared to regular breakfast. There was no significant difference in incremental area under the curve or peak plasma level between the breakfasts containing apple and lentil (4814.9±3041.9 mg/dl/min and 4352±2231.9 mg/dl/min respectively). The incremental area under glycemic response curve with regular breakfast (8469.9± 4174.5 mg/dl/min) showed significant reduction compared to the breakfasts containing apple or lentil (apple, p<0.02 and lentil, p<0.005). Peak glucose level was also significantly lower with the breakfasts containing apple or lentil (apple p<0.01 and lentil p<0.002).
Conclusion: It seems that half replacement of bread with the same unit of apple and lentil in regular breakfast has similar effects on blood glucose. Thus these replacements can be recommended to improve blood glucose response in type 2 diabetics.

 
Keyword(s): TYPE 2 DIABETES, GLYCEMIC RESPONSE, MIXED MEAL
 
References: 
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