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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2004 , Volume 9 , Number 4 (40); Page(s) 225 To 230.
 
Paper: 

PREVALENCE OF PREECLAMPSIA, ECLAMPSIA AND THEIR RELATED FACTORS IN WOMEN REFERRING TO MEDICAL UNIVERSITY HOSPITALS IN TEHRAN, 2001

 
 
Author(s):  AMIR ALI AKBARI S., DOULATIAN M., VALAEI NASER
 
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Abstract: 
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Background: One of the most important and urgent problems during prenancy is preeclampsie which can lead to eclampsia. In this condition, early diagnosis and treatment of the disease is so critical for prevention of the fatal consequences. The first stage of this study was conducted to determine the prevalence of preeclampsia and eclampsia as well as their related factors with respect to controversial reports regarding the topic.
Materials and methods: Subject population randomly selected consisted of 4856 women in their 20th or more week of gestation referring to university hospitals in Tehran in 2001. Diagnostic criteria for preeclampsia included blood pressure (BP) of 140/90 mmHg, 30 mmHg and 15 mmHg rise in systolic and diastolic BPs, respectively as well as generalized edema specially in hands and face and proteinuria above 300 mg/dl or more in 24 hour urine collection or above 100 mg/dl in two urine specimens over 6 hours. The women who had convulsions associated with the above mentioned signs were diagnosed as eclamptic. Accordingly, the prevalence was then calculated (CI, %95).
In the second stage, a case – control design was applied to determine the role of related factors in the incidence of preeclampsia and eclampsia. Women with preeclampsia or eclampsia were considered as case group. Control group were unaffected women referring to the same hospitals whose matched by age, educational level, occupation, living place (city or country), and smoking with case group. Economic status, familial relationship with spouse, blood group, history of hypertension as well as preeclampsia or eclampsia in close family members, first pregnancy, history of preeclampia and eclampsia and also BMI factors, quality of prenatal care, severe pica, intervals of gestation, contraceptive technique, and Rh were statistically correlated with the prevalence of the two conditions.
Results: 143 women (%3) had preeclampsia and 8 women (%0.16) had eclampsia. The case group (151 affected women) and 378 unaffected women (the control group) were compared. The mean age (±s.e.) of case (151 women) and control (378 women) groups were 26±6.3 and 25.95 ± 5.6, respectively. There was no difference in the educational level, occupation, living place, and smoking between groups. %25.8 of the case group and %3.7 of the control group had the history of preeclampsia (P<0.0001). There was also a significant difference between blood group B in case group (%16.6) and in control group (%2.1) (P<0.0001), low economic status in case (63.6) and control (%51.8) groups (P<0.01), history of hypertension in case (%16.6) and control (%2.1) groups (P<0.0001), familial relationship with spouse in case (%37.1) and control (%27) groups (P<0.02), familial history of preeclampsia and eclampsia in case (%15.4) and control (%6.8) groups (P<0.003), and first pregnancy in case (%36.5) and control (%45) groups (P<0.08). There was no significant difference in other factors.
Conclusion: According to the results, it can be concluded that these conditions are not the matter of concern in Tehran city. Further experimental studies concerning monitoring pregnant women with the history of preeclampsia and eclampsia, blood group B, the history of hypertension, low economic status, and familial relationship with spouse in connection with the prevalence of both conditions are warranted.

 
Keyword(s): PREECLASMPIA, ECLAMPSIA, PREVALENCE, RELATED FACTORS
 
References: 
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