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Paper Information

Journal:   AUDITORY AND VESTIBULAR RESEARCH   2012 , Volume 21 , Number 4; Page(s) 19 To 27.
 
Paper: 

EVALUATION OF COGNITIVE DISORDERS IN MULTIPLE SCLEROSIS PATIENTS BY AUDITORY EVENT RELATED POTENTIAL

 
 
Author(s):  RASOULIFARD PARISA, MOHAMMADKHANI GHASEM*, FARAHANI SAEED, SAHRAIYAN MOHAMMADALI, JALAIE SHOHREH
 
* DEPARTMENT OF AUDIOLOGY, SCHOOL OF REHABILITATION, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, NEZAM ALLEY, SHAHID SHAHNAZARI ST., MADAR SQUARE, MIRDAMAD BLVD., TEHRAN, 15459-13487, IRAN
 
Abstract: 

Background and Aim: The involvement of central auditory nervous system is relatively prevalent in patients suffering from multiple sclerosis (MS). To understand cortex function and to investigate cognitive impairment, event related potential is considered as a valuable tool. This study was aimed to compare the amplitude and latency of the event related potentials of P300 in MS patients and normal individuals.
Methods: This cross sectional study was conducted on 21 MS patients and 27 normal cases aged 18-50 years. Auditory P300 was recorded with oddball paradigm, using two tone burst stimuli (1000 and 2000).
Results: In MS patients, mean latencies were significantly longer (p<0.001) and mean amplitude were significantly lower (p<0.001), in both males and females. Sex did not affect P300 latencies and amplitudes significantly.
Conclusion: MS patients show some degree of event related potential abnormalities. Combination of auditory P300 and neuropsychological tests may be useful to investigate cognitive impairment in MS patients.

 
Keyword(s): MULTIPLE SCLEROSIS, EVENT RELATED POTENTIAL, TONE BURST STIMULATION
 
References: 
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