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Paper Information

Journal:   ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES   2013 , Volume 1 , Number 2; Page(s) 87 To 91.
 
Paper: 

URINARY TUMOR NECROSIS FACTOR-ALPHA A GOOD INDICATOR FOR INFLAMMATORY RESPONSE IN PYELONEPHRITIS

 
 
Author(s):  MOHKAM MASOUMEH*, RAFIEI TABATABAEI SEDIGHEH, ASGARIAN FAHIMEH, ARMIN SHAHNAZ, FAHIMZAD ALIREZA, SHARIFIAN MOSTAFA, DALIRANI REZA
 
* PEDIATRIC INFECTIONS RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Background: TNF-a is one of the most potent cytokines in proinflammatory reactions.
Objectives: This article contributes to evaluate the correlation between urinary TNF-
a and inflammatory response markers in children with acute pyelonephritis.
Patients and Methods: This cross sectional study, was performed on children with acute pyelonephritis. Fresh random urine samples were obtained before treatment of pyelonephritis. Urine samples were tested for TNF-α and creatinine. We also evaluated our patients with routine biochemical studies.
Results: One hundred and twenty children with acute pyelonephritis were evaluated. Urinary TNF-
a/Cr was 0.0051 ± 0.00083 Pg/g creatinine. The authors found out a significant difference in urinary TNF-a/Cr between patients who have normal and abnormal levels of urine leukocytes, urine protein, urine culture, erythrocyte sedimentation rate and C- reactive protein. This study revealed a significant correlation between urinary TNF-alpha and urine WBC (r = 0.36, P value = 0.02), ESR (r = 0.75, P value = 0.03) and CRP (r = 0.58, P value = 0.02).
Conclusions: We concluded that urinary TNF-
a/Cr might be a good indicator for inflammatory response in children with acute pyelonephritis.

 
Keyword(s): TUMOR NECROSIS FACTOR-ALPHA, PEDIATRICS, PYELONEPHRITIS
 
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