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Paper Information

Journal:   JOURNAL OF CURRENT OPHTHALMOLOGY   2002 , Volume 14 , Number 1; Page(s) 22 To 30.
 
Paper: 

COMPARISON OF LASER EPITHELIAL KERATOMILEUSIS AND PHOTO REFRACTIVE KERATECTOMY FOR LOW TO MODERATE I MYOPIA: A RANDOMIZED CLINICAL STUDY

 
 
Author(s):  HASHEMI H., FOTOUHI A., PAYVAR S., FOUDAZI H., SADEGHI N.
 
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Abstract: 

Purpose: To compare the effectiveness, safety and patient satisfaction following laser epithelial keratomileusis (LASEK) and photo refractive keratectomy (PRK) for low to moderate myopia.
Methods: Eighty-four eyes of 42 myopic patients were enrolled in this prospective, randomized, paired clinical study. Each patient received LASEK on one eye and PRK on the other eye; procedure assignment to each eye, and the sequence of operations for each patient was randomized. Before surgery, mean spherical equivalent of refractive error (SE) was-3.57 diopters (D) ±1.25 (SD)(range,-1.50 to -6.50 D) in the LASEK eyes and -3.44 D ±1.13 (SD) (range, -1.60 to -6.00 D) in the PRK eyes. Patients were visited on the first 7 days, and 1 and 3 months after surgery. Patient satisfaction and quality of vision were assessed using a subjective questionnaire.
Results: In the first 7 days and at 1 month after surgery, all patients (100%) and at 3 months, 32 patients (76%) came for follow-up. At 3 months, 32 (100%) of LASEK eyes and 31 (97%) of PRK eyes had an uncorrected visual acuity of 20/40 or better; 25 (79%) of LASEK eyes and 26 (82%) of PRK eyes had uncorrected visual acuity of 20/20 or better (P=0.959), mean spherical equivalent refraction was 0.08 D ±0.53 (SD) in LASEK eyes and 0.12 D± 0.50 (SD) in PRK eyes (P=0.652), 26 (81%) of LASEK eyes and 23 (72%) of PRK eyes had a SE within± 0.50 D and 29 (91%) of LASEK eyes and 30 (94%) of PRK eyes had a SE within± 1.00 D. The epithelial healing time was 3.97 days± 1.27 (SD) in LASEK group and 3 69 days ± 1.03 (SD) in PRK group (P=0.078). Mean subjective pain score in the scale of 0 to 3 (3 for severe) was 1.07±0.75 (SD) in LASEK eyes and 0.85±0.73 (SD)in PRK eyes on the first day after operation (P=0.183). At 1 month and 3 months after surgery, the grade of haze was not statistically different in the two groups. Patients were similarly satisfied with both techniques.
Conclusions: In this study, LASEK and PRK were found to have similar effectiveness, safety, and predictability for treatment of low to moderate myopia. LASEK, as a modified PRK, was not found to have any advantage to PRK considering postoperative pain, epithelial healing and corneal haze.

 
Keyword(s): MYOPIA, LASEK, PRK, CLINICAL TRIAL
 
References: 
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