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Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   Winter 2002 , Volume 6 , Number part 4; Page(s) 253 To 260.
 
Paper: 

ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE

 
 
Author(s):  RAHMANI M., RAIS ZADEH F., SOULATI M., HEDAYATI S.M., MIROULIAEI M., *
 
* Shaheed Beheshti Medical Sciences University, Tehran, IR IRAN.
 
Abstract: 
The association of serum apolipoprotein (apo) A-I and apo B concentrations, and paraoxonase (PON) enzyme activity with angiographically determined coronary artery disease (CAD) was investigated in Iranian nondiabetic patients with premature CAD and normal coronary artery control subjects in a sex and age matched case-control study. The study population consisted of 59 nondiabetics subjects with premature CAD (25 men and 34 women) and 55 CAD- controls (21 men and 34 women) who were referred for their first coronary angiography. Premature CAD was defined as presence of angiographically detected coronary stenosis (> 50% in 1 or more coronary arteries) in men younger than 55 and in women younger than 65 years of age. CAD- was defined as a maximum stenosis of 10% in any coronary artery. All study participants had fasting blood sugar levels of less than 140 mg/dl and had no history of taking oral hypoglycemic agents. Apo concentrations were measured by immunoturbidometric assay and Pon/arylesterase activities by spectrophotometric assay of p-nitrophenol/phenol production following addition of paraoxon /phenylacetate to serum. No significant difference was observed in mean age of CAD and control groups (52.5 ± 6.4 vs 52.5 ± 7.4). In CAD patients, increased concentration of total cholesterol (215 ± 43 vs 193 ± 43, P<0.05) triglycerides (169 ± 125 vs 156 ± 118, P<0.05) LDL-C (138 ± 46 vs 116 ± 39, P<0.05) and apo B (102 ± 24 vs 84 ± 17.5, P+ group and CAD- controls was apo B. It is concluded that in Iranian nondiabetic patients with premature CAD, the concentration of apo B is a better marker than traditional lipid parameters in discriminating between CAD+ and CAD- subjects. Lack of significant difference in poN activity berween CAD+ patients and CAD- controls supports the concept of interethnic variability in poN polymorphism observed in other studies.
 
Keyword(s): CORONARY ARTERY DISEASE, LIPOPROTEIN, APOLIPOPROTEIN, PARAOXONASE.
 
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