Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   September 2004 , Volume 3 , Number 3; Page(s) 121 To 125.
 
Paper: 

THE EFFECT OF RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR (R-TPA) ON QUANTITATION OF NEUTRALISING ANTI-STREPTOKINASE ANTIBODIES

 
 
Author(s):  AFSHARI A.GH.*, ELIZBETH HOLME R.
 
* Immunology Department, Qazvin University of Medical Sciences, Qazvin, Iran
 
Abstract: 

The measurement of anti-streptokinase antibodies can distinguish the patients who may benefit from streptokinase and those who should be treated with some other thrombolytic regimen. Neutralising titration test is a commonly used classical assay for measuring anti-streptokinase antibodies and in this assay the ability of anti-streptokinase antibodies in patients sera in preventing the lytic effect of streptokinase is assessd. As we showed previously the presence of r-tPA in the serum may interefere with the neutralising titration test, we investigated this interference in vitro. The level of neutralising anti-streptokinase antibodies in a serum sample with known levels of the antibodies were measured in absence and presence of increasing amount of r-tPA including therapeutic values. Increasing amount of r-tPA in vitro induced a sudden reduction in the measurable titre of anti-streptokinase antibody levels in a serum with elevated levels of anti-streptokinase antibodies. This effect of r-tPA, which is through activation of plasminogen has not been reported previously. We suggest this assay is unsuitable for clinical diagnosis of anti-streptokinase antibodies.

 
Keyword(s): ANTISTREPTOKINASE, ANTIBODIES, TISSUE PLASMINOGEN ACTIVATOR
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 91
 
Latest on Blog
Enter SID Blog