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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   July 2005 , Volume 8 , Number 3; Page(s) 219 To 220.
 
Paper: 

OPTIMAL MAINTENANCE DOSE OF WARFARIN IN PATIENTS WITH PROSTHETIC HEART VALVES IN KERMANSHAH, WEST OF IRAN

 
 
Author(s):  SALIMI A.R.*, MOLUDI A.R.
 
* Kermanshah University of Medical Sciences, Imam Khomeini Hospital 67187 Naghlieh Ave., Kermanshah,
 
Abstract: 
Warfarin is a widely-used anticoagulant drug in clinical practice. However, its use is with caution due to serious side effects including gastrointestinal bleeding (up to 5%) and mortality (0.5% – 2.0%). Therefore, the correct dosing of warfarin is of paramount importance. We examined warfarin maintenance dose requirements in 115 outpatients in Kermanshah, North-West of Iran, who had a history of isolated aortic or mitral valve replacement and were on stable maintenance doses of warfarin with international normalized ratios (INR) of 2.0 – 2.5. The mean daily warfarin requirement was 4.6 ± 1.8 mg, with 75% of patients requiring < 5 mg/day. No significant difference was noted between the two sex groups; however, there was a noticeable decline in dose requirement by increasing age.
This study suggests that a relatively small dose (as low as 5 mg) of warfarin is required for maintaining anticoagulation in our patients.
 
Keyword(s): ANTICOAGULANT · HEART VALVE REPLACEMENT · INTERNATIONAL NORMALIZED RATIO · PROTHROMBIN TIME (PT) · WARFARIN
 
References: 
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