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Paper Information

Journal:   MODARES JOURNAL OF MEDICAL SCIENCES (PATHOBIOLOGY)   Spring-Summer 2004 , Volume 7 , Number 1; Page(s) 49 To 59.
 
Paper: 

EFFECT OF ADENOSINE A1 RECEPTORS ACTIVITY OF NUCLEUS ACCUMBENS ON AMYGDALA KINDLED SEIZURES IN RATS

 
 
Author(s):  ROZATI S.A., MIRNAJAFIZADEH S.J.*, FATH ELAHI Y., MOHAMMADZADEH M., PALIZVAN M.R.
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCE, TARBIAT MODARRES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Purpose: The role of adenosine AI receptors of the nucleus accumbens on amygdala kindled seizures was investigated.
Materials and Methods: All animals were implanted with a triplolar (stimulating and recording) electrode in the amygdala and tow guide cannula in the nucleus accumbens. Animals were kindled by daily electrical stimulating of the amygdala. In the full kindled animals, N6- cyclohexyladenosine (CHA; 1, 5 , 10 µM), an adenosine A1 receptor agonist, was injected bilaterally into the nucleus accumbens.
Results: Obtained results showed that CHA at the concentration of 10µM reduces the amygdala afterdischarge duration (A-ADD), at 5, 15, 60 and 120 min post drug injection. It also decreased the stage 5 duration (S5D), but reduced the accumbens afterdischarge duration (Acc-ADD), at 15 min post drug injection, and increased the latency of the stage 4 seizure (S4L) at 5 and 15min post drug infusion. In addition, at the concentration of 5 µM, the S4L was increased and the S5D was decreased at 5 and 15 minpost drug injection. The bilateral injection of8- cyclopenthyl-l,3- dimethylxanthine (CPT), an adenosine A1 receptor antagonist, at the concentration of 5 µM into the nucleus accumbens did not alter the seizure parameters. The intra- nucleus accubens infusion of CPT (5µM), 5 min before CHA (10µM) blocked the anticonvulsant effects of CHA.
Conclusion: These results suggest that the nucleus accumbens has a role in the seizure propagation from the amygdala and it's adenosine AI receptors activity has anticonvulsant effects in amygdala kindled rats.

 
Keyword(s): SEIZURE, ADENOSINE, AMYGDALA, NUCLEUS ACCUMBENS, KINDLING
 
References: 
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