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Paper Information

Journal:   PAJOUHESH-VA-SAZANDEGI   SUMMER 2001 , Volume 14 , Number 2 (51 IN ANIMAL SCIENCES); Page(s) 35 To 38.
 
Paper: 

BIOLOGICAL CHARACTERISTICS OF BRUCALLA ABORTUS STRAIN RB51

 
 
Author(s):  ZOWGHI E., EBADI A., YARAHMADI M., KHODASHENAS M.
 
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Abstract: 
A rifampin-penicillin resistant mutant of Brucella abortus was derived by repeated passage of smooth strain 2308 on specific brucella agar medium with varying concentrations rifampin and pencillin, and designated RB51. This strain is rough and its colonies absorbed crystal violet and auto agglutinated with acriflavine, No o - Chain component was detected in lipopolysaccharide of RB51 and therefore, it doesn't induce humoral antibodies in animals injection. Biochemically RB51 resembles parental strain 2308 in its ability to utilize erythritol. Subcutaneously inoculation of RB51 into BALB/C mice and guinea-pigs results in a splenic colonization which is cleared within 3 and 4 weeks post infection respectively.
Also, interaperitoneal inoculation of RB51 into mice results in splenic colonization that is cleared after 3 weeks. RB51 is a stable strain and doesn't revert to smooth phase upon passage in vitro and in vivo. The proteins antigenic structure of RB51 resembles to smooth strains. Immunization of BALB/c mice with 2x108 and guinea - pigs with 2x109 viable organisms confers significant protection against challenge with virulent Brucella abortus strain 544.
 
Keyword(s): BRUCELLA ABORTUS, BIOLOGY, RB51 STRAIN, VACCINE
 
References: 
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