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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   2003 , Volume 32 , Number 4; Page(s) 8 To 12.
 
Paper: 

PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN

 
 
Author(s):  MASOUD A.*, KESHAVARZ H., MAHBOUDI F.
 
* Iran
 
Abstract: 
Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 Plasmodium falciparum isolates of malarial patients from southern areas of Iran, showed 4 different situations: i- wild type (108-Ser) ii-mutant type (108-Thr) iii-mutant type (108-Asn) and iv-mixed wild and mutant type (108-Ser+Thr) with frequency of 58(82.8%), 2(2.9%), 8(11.4%) and 2(2.9%) respectively. Many studies have demonstrated that mutations in position 108 have key role for emerging resistance to anti-folate drugs in falciparum malaria so, the resistance to pyrimethamine and proguanil, presents in Plasmodium falciparum isolates from malarious endemic regions of Iran.
 
Keyword(s):  PLASMODIUM FALCIPARUM, DRUG RESISTANCE, PYRIMETHAMINE, PROGUANIL, IRAN
 
References: 
 
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